4'-Hydroxyacetophenon

Bezeichnung:4'-Hydroxyacetophenon

CAS-Nr99-93-4

Englisch Name:4'-Hydroxyacetophenone

CBNumberCB7198612

SummenformelC8H8O2

Molgewicht136.15

MOL-Datei99-93-4.mol

Synonyma

4'-Hydroxyacetophenon

4'-Hydroxyacetophenon physikalisch-chemischer Eigenschaften

Schmelzpunkt	132-135 °C(lit.)
Siedepunkt	147-148 °C3 mm Hg(lit.)
Dichte	1.109
Dampfdruck	0.002Pa at 20℃
Brechungsindex	1.5577 (estimate)
FEMA	4330 \| 4-HYDROXYACETOPHENONE
Flammpunkt	166 °C
storage temp.	Store below +30°C.
Löslichkeit	methanol: 0.1 g/mL, clear
Aggregatzustand	Crystalline Powder
pka	8.05(at 25℃)
Wichte	1.109
Farbe	Almost white to beige
Geruch (Odor)	at 10.00 % in dipropylene glycol. mild sweet hawthorn balsam mimosa
Geruchsart	floral
Wasserlöslichkeit	10 g/L (22 ºC)
JECFA Number	2040
BRN	774355
InChIKey	TXFPEBPIARQUIG-UHFFFAOYSA-N
LogP	1.35 at 25℃
CAS Datenbank	99-93-4(CAS DataBase Reference)
NIST chemische Informationen	Acetophenone, 4'-hydroxy-(99-93-4)
EPA chemische Informationen	4-Hydroxyacetophenone (99-93-4)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	36/37/38-22
S-Sätze:	26-36/37-37/39-24/25-22-36
WGK Germany	3
RTECS-Nr.	PC4959775
Hazard Note	Irritant
TSCA	Yes
HS Code	29145000

Gefahreninformationscode (GHS)

4'-Hydroxyacetophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White to beige powder; sweet, hawthorn, balsam, mimosa aroma
Chemische Eigenschaften
almost white to beige crystalline powder
Occurrence
Reported found in cloudberry, coffee, cranberry, mango, sherry, and wort.
Verwenden
4?-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.
Verwenden
p-Hydroxyacetophenone is widely used in medicine, cosmetics and industrial fields. It is a natural plant extract, which naturally exists in the stems and leaves of the Compositae plant, Artemisia annua, the roots of plants such as Artemisia annua, Rhododendron, and Panax ginseng. It has a good effect on yellow eyes caused by diseases such as hepatitis, and also has a good auxiliary effect on yellow eyes caused by various reasons. Due to its weak molecular activity, high temperature resistance, melting point of 95-97 °C and boiling point of 296 °C, it is widely used in various liquid pharmaceuticals and can prolong the shelf life of other active ingredients under high temperature conditions. It has no harm to human skin and is the safest high-temperature auxiliary active stabilizer in the pharmaceutical industry.
Verwenden
4′-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.
Application
4'-Hydroxyacetophenone has been suggested for use in perfume compositions as a modifier for the more conventional derivatives of Acetophenonc, etc. mainly in heavy-floral or woodyfloral fragrances where power and low cost arc requested.
Vorbereitung Methode
4'-Hydroxyacetophenone can be produced 1) from Phenylacetate by heating with Aluminum chloride. 2) from Phenol, Acetylchlonde and Aluminum chloride by Friedel-Craft' reaction.
Definition
ChEBI: A monohydroxyacetophenone carrying a hydroxy substituent at position 4'.
synthetische
Preparation by Fries rearrangement of phenyl acetate with Lewis acids
aluminium chloride
in nitrobenzene at 20–25° or at 50–60°
in chlorobenzene between 45° and 65°, sealed tube and subjected to high power microwave irradiation for 2 min only (36%)
in nitroethane at 60° (44%)
in carbon disulfide at 45° (40%)
in petroleum ether at 50° (20%)
but between 130° and 175° (40–60%)
aluminium chloride–sodium chloride mixture at 240–250° (10%)
boron trifluoride at 90° (56%)
scandium tris(trifluoromethanesulfonate), in nitromethane, at 50° (39%)
titanium tetrachloride at 90–100° (34%)
ferric chloride at 65° (25%)
zinc chloride at 125° (8%)
hydrofluoric acid, between 20° and 100° (94%)
polyphosphoric acid, between 20° and 100° (69%) (50–53%)(44%)
Nafion-XR 500, sulfonic acid type at 100°
ZSM-5, in sulfolane, at 180° (28%)
H-ZSM-5 at 400° or at 210° (6%)
H-Nu-2 at 170° (15%)
HY (Si/Al = 3) or fluorided alumina (Al2O3-F; 3 % wt. F), at 400°.
Aroma threshold values
Floral type, medium strength odor; recommend smelling in a 10.00% solution or less.
Synthesis Reference(s)
Tetrahedron Letters, 32, p. 5829, 1991 DOI: 10.1016/S0040-4039(00)93567-6
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Flammability and Explosibility
Non flammable
läuterung methode
Crystallise it from diethyl ether, aqueous EtOH or *benzene/pet ether. [Beilstein 8 H 87, 8 IV 339.]

4'-Hydroxyacetophenone Upstream-Materialien And Downstream Produkte

4'-Hydroxyacetophenon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

99-93-4, 4'-Hydroxyacetophenone Verwandte Suche:

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