Progesteron Produkt Beschreibung

Progesterone Struktur
57-83-0
  • CAS-Nr.57-83-0
  • Bezeichnung:Progesteron
  • Englisch Name:Progesterone
  • Synonyma:Progesteron
    CIDR;Lutex;Lutin;U 3672;Lutein;Luteol;Luteum;lutren;Prolets;Luteine
  • CBNumber:CB4224484
  • Summenformel:C21H30O2
  • Molgewicht:314.46
  • MOL-Datei:57-83-0.mol
Progesteron physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :128-132 °C(lit.)
  • alpha  :186 º (c=1, ethanol)
  • Siedepunkt: :394.13°C (rough estimate)
  • Dichte :d23 1.166; d20 1.171
  • Brechungsindex :182 ° (C=2, Dioxane)
  • Flammpunkt: :2℃
  • storage temp.  :Store at RT
  • Löslichkeit :H2O: 25 mg/mL, may be clear to slightly hazy
  • Aggregatzustand :powder
  • Farbe :Yellow to yellow-brown
  • Wasserlöslichkeit :<0.1 g/100 mL at 19 ºC
  • Merck  :7773
  • BRN  :1915950
  • Stabilität: :Stable. Incompatible with strong oxidizing agents.
  • InChIKey :RJKFOVLPORLFTN-LEKSSAKUSA-N
  • CAS Datenbank :57-83-0(CAS DataBase Reference)
  • NIST chemische Informationen :Progesterone(57-83-0)
  • EPA chemische Informationen :Pregn-4-ene-3,20- dione(57-83-0)
Sicherheit

Progesterone Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R40:Verdacht auf krebserzeugende Wirkung.
    R45:Kann Krebs erzeugen.
  • S-Sätze Betriebsanweisung: S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
    S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
  • Chemische Eigenschaften White powder. Melting point 121°C. Stable in air. Insoluble in water. A female sex hormone. Low toxicity.
  • Occurrence Colchicum luteum also yields this alkaloid.
  • Verwenden Sterid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer
  • Definition ChEBI: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and ot er species.
  • Definition progesterone: hormone, producedprimarily by the corpus luteumof the ovary but also by theplacenta, that prepares the inner liningof the uterus for implantation ofa fertilized egg cell. If implantationfails, the corpus luteum degeneratesand progesterone production ceasesaccordingly. If implantation occurs,the corpus luteum continues to secreteprogesterone, under the influenceof luteinizing hormone andprolactin, for several months of pregnancy,by which time the placentahas taken over this function. Duringpregnancy, progesterone maintainsthe constitution of the uterus andprevents further release of eggs fromthe ovary. Small amounts of progesteroneare produced by the testes.
  • Trademarks Crinone (Columbia); Prometrium (Unimed).
  • Allgemeine Beschreibung Progesterone, pregn-4-en-3,20-dione, is so rapidly metabolized that it is not particularlyeffective orally, being only one twelfth as active as intramuscularly.An oral formulation of micronized progesterone(Prometrium) is available. Progesterone given intramuscularlycan be very irritating. A vaginal gel containing 4% or8% progesterone offers an alternative dosage form.Progesterone was originally obtained from animal ovariesbut is now prepared synthetically from plant sterol precursors.The discovery of 19-nortestosterones with progesteroneactivity made synthetically modified progestins of tremendoustherapeutic importance.
    Progesterone (and all other steroid 4-ene-3-ones) is lightsensitive and should be protected from light.
  • Air & Water Reaktionen Insoluble in water.
  • Reaktivität anzeigen Progesterone is sensitive to light .
  • Hazard A carcinogen (OSHA).
  • Health Hazard ACUTE/CHRONIC HAZARDS: Progesterone may be absorbed through the skin.
  • Brandgefahr Flash point data for Progesterone are not available; however, Progesterone is probably combustible.
  • Biologische Aktivität Endogenous progesterone receptor (PR) agonist (EC 50 = 0.5 nM).
  • Sicherheitsprofil NTP 10th Report on Carcinogens. IARC Cancer Review: Animal Lirmted Evidence IMEMDT 21,491,79; Animal Sufficient Evidence IMEMDT 6,135,74. EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory. SAFETY PROFILE: Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by intravenous and intraperitoneal routes. Human teratogenic effects by ingestion and parenteral routes: developmental abnormalities of the urogenital system. Human male reproductive effects by intramuscular route: changes in spermatogenesis, the prostate, seminal vesicle, Cowper's gland and accessory glands, impotence, and breast development. Human female reproductive effects by ingestion, parenteral, and intravaginal routes: ferthty changes; menstrual cycle changes and disorders; uterus, cervix, and vagina changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Carcinogenicity Progesterone is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
  • läuterung methode The form crystallises from EtOH with m 127-131o. The -form crystallises from pet ether or aqueous pet ether/aqueous Et2O with m 119-120o or 121o. It also crystallises from Et2O, Me2CO/EtOAc, MeOH, aqueous Et2O, aqueous MeOH, wet pet ether, Et2O/pet ether, pet ether/*C6H6, Et2O/pentane and isopropyl ether. The is at 240nm with log 4.25 (EtOH). [Wintersteiner & Allen J Biol Chem 107 max 321 1934, Beilstein 7 III 3648, 7 IV 2395.]
  • Verordnung (Regulations) Consumer Product Safety Commission (CPSC)
    Any orally administered prescription drug for human use requires child-resistant packaging.
    Food and Drug Administration (FDA)
    Progesterone is a prescription drug subject to labeling and other requirements.
    Maximum levels of progesterone in edible animal tissues are prescribed in 21 CFR 556.540.
    Progesterone in topically applied hormone-containing drugs for over the counter use is no longer considered generally recognized as safe and effective.
Progesterone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Progesteron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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57-83-0, Progesterone Verwandte Suche:
  • progesterone(INN)
  • Progesteronum
  • Progestogel
  • Progestol
  • Progeston
  • Progestone
  • Progestosol
  • Progestron
  • Progestronol
  • Progstin
  • projestaject
  • Prolets
  • Prolidon
  • Prolutin
  • Proluton
  • Prolutone
  • Protormone
  • Syngesterone
  • synGestrets
  • Synovex S
  • synovexs
  • synTolutan
  • Thiuram E
  • Thiuranide
  • Utrogestan
  • PROGESTERONE GAMMA-IRRADIATED*CELL CULTU RE TESTED
  • PROGESTERONE VETRANAL, 250 MG
  • ProgesteroneAndProgesteroneMicronize
  • 10%Beadlet
  • CIDR
  • Progestan
  • Vitarrine
  • PROGESTERONE,MICRONIZEDPOWDER,USP
  • PROGESTERONE,MILLEDPOWDER,USP
  • PROGESTERONE,ORAL(YAM),MICRONIZEDPOWDER,USP
  • PROGESTERONE,TOPICAL,MICRONIZEDPOWDER,USP
  • PROGESTERONE,WETTABLE,POWDER,USP
  • (8S,9S,10R,13R,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
  • PROGESTERONE(SH)
  • PROGESTERONE(PREGN-4-ENE-3,20-DIONE)
  • D4-Pregnene-3,20-dione
  • NSC 64377
  • Pregn-4-ene-3,20-dione (9CI)
  • Progeffik
  • Prometrium
  • Prontogest
  • U 3672
  • Utrogest
  • PROG ELISA
  • Progestrone
  • 3-KETOBISNOR-4-CHLONALDEHYE
  • Lutein
  • PROCYANIDINS
  • Progesterone: 2-hydroxypropyl-β-cyclodextrin complex, Progesterone: HBC complex
  • Progesterone, Powder, Micronized
  • Progesterone, Powder, Milled
  • Progesterone, Powder, Wettable
  • Progesterone solution,100ppm