Hydrocortison-21-acetat

Bezeichnung:Hydrocortison-21-acetat

CAS-Nr50-03-3

Englisch Name:Hydrocortisone acetate

CBNumberCB7196805

SummenformelC23H32O6

Molgewicht404.5

MOL-Datei50-03-3.mol

Synonyma

Hydrocortison-21-acetat

Hydrocortison-21-acetat physikalisch-chemischer Eigenschaften

Schmelzpunkt	223 °C (dec.)(lit.)
Siedepunkt	446.1°C (rough estimate)
alpha	D25 +166° (c = 0.4 in dioxane); D25 +150.7° (c = 0.5 in acetone)
Dichte	d420 1.289
Brechungsindex	1.4593 (estimate)
Flammpunkt	223°C
storage temp.	0-6°C
Löslichkeit	Practically insoluble in water, slightly soluble in anhydrous ethanol and in methylene chloride
pka	12.42±0.70(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	Insoluble in water.
Decomposition	223 ºC
Merck	14,4787
BRN	2066841
Stabilität	Stable, but may be light or moisture sensitive. Incompatible with strong oxidizing agents.
LogP	2.190
CAS Datenbank	50-03-3(CAS DataBase Reference)
NIST chemische Informationen	Hydrocortisone acetate(50-03-3)

Sicherheit

Kennzeichnung gefährlicher	Xn,T
R-Sätze:	63-10-45
S-Sätze:	36/37-45-53
WGK Germany	3
RTECS-Nr.	GM8960000
HS Code	29372100
Toxizität	LD50 intraperitoneal in mouse: 2300mg/kg

Gefahreninformationscode (GHS)

Hydrocortisone acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
white powder
Verwenden
Hydrocortisone acetate is used to treat hemorrhoids and itching/swelling in the rectum and anus. It is used to treat certain intestinal problems (such as ulcerative colitis of the rectum and other rectal/anal inflammatory conditions).
Verwenden
Glucocorticoid
Definition
ChEBI: Cortisol 21-acetate is a tertiary alpha-hydroxy ketone and a cortisol ester.
Trademarks
Cortef Acetate (Pharmacia & Upjohn); Cortifoam (Schwarz Pharma); Cortril (Pfizer); Dricort (Ingram); Hydrocortone (Merck).
Clinical Use
Corticosteroid:

Local inflammation of joints and soft tissue
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Aldesleukin: avoid concomitant use.
Antibacterials: metabolism accelerated by rifampicin; metabolism possibly inhibited by erythromycin; concentration of isoniazid possibly reduced.
Anticoagulants: efficacy of coumarins and phenindione may be altered.
Antiepileptics: metabolism accelerated by carbamazepine, phenobarbital, fosphenytoin, phenytoin and primidone.
Antifungals: increased risk of hypokalaemia with amphotericin - avoid; metabolism possibly inhibited by itraconazole and ketoconazole.
Antivirals: concentration possibly increased by ritonavir.
Ciclosporin: rare reports of convulsions in patients on ciclosporin and high-dose corticosteroids
. Cobicistat: concentration of hydrocortisone possibly increased - increased risk of adrenal suppression.
Diuretics: enhanced hypokalaemic effects of acetazolamide, loop diuretics and thiazide diuretics.
Vaccines: high dose corticosteroids can impair immune response to vaccines - avoid concomitant use with live vaccines.
Stoffwechsel
Hydrocortisone is metabolised in the liver and most body tissues to hydrogenated and degraded forms such as tetrahydrocortisone and tetrahydrocortisol. These are excreted in the urine, mainly conjugated as glucuronides, with a very small proportion of unchanged hydrocortisone.
läuterung methode
The acetate recrystallises from Me2CO/Et2O or aqueous Me2CO as hygroscopic monoclinic crystals. UV has max at 242 nm (A1cm 1% 390) in MeOH. Its solubility at 25o is: H2O (0.001%), EtOH (0.45%), MeOH (0.04%), Me2CO (1.1%), CHCl3 (0.5%), Et2O (0.15%), and it is very soluble in Me2NCHO. [Wendler et al. J Am Chem Soc 74 3630 1952; Antonucci et al. J Org Chem 18 7081 1953, Beilstein 8 IV 3424.]

Hydrocortisone acetate Upstream-Materialien And Downstream Produkte

Hydrocortison-21-acetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

50-03-3, Hydrocortisone acetate Verwandte Suche:

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