Hydrocortison-21-(natriumsuccinat)

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Sicherheit

  P201：Vor Gebrauch besondere Anweisungen einholen.

  P308+P313：BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

Hydrocortisone sodium succinate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Hydrocortisone Hemisuccinate Sodium is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone Hemisuccinate Sodium is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc.

• Verwenden

  Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity (IC50 = 6.7 μM for IL-6). It is commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells.

• Verwenden

  Hydrocortisone sodium succinate is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone sodium succinate is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc.

• Definition

  ChEBI: Hydrocortisone Sodium Succinate is an organic molecular entity.

• Trademarks

  A-Hydrocort (Abbott); A-Hydrocort (Hospira); Solu-Cortef (Pharmacia & Upjohn).

• Allgemeine Beschreibung

  Hydrocortisone for use in epithelial and endothelial adherent cell culture applications.

• Arzneimittelwechselwirkung

  Potentially hazardous interactions with other drugs
  Aldesleukin: avoid concomitant use.
  Antibacterials: metabolism accelerated by rifampicin; metabolism possibly inhibited by erythromycin; concentration of isoniazid possibly reduced.
  Anticoagulants: efficacy of coumarins and phenindione may be altered.
  Antiepileptics: metabolism accelerated by carbamazepine, fosphenytoin, phenobarbital, phenytoin and primidone.
  Antifungals: increased risk of hypokalaemia with amphotericin - avoid; metabolism possibly inhibited by itraconazole and ketoconazole.
  Antivirals: concentration possibly increased by ritonavir.
  Ciclosporin: rare reports of convulsions in patients on ciclosporin and high-dose corticosteroids.
  Cobicistat: concentration of hydrocortisone possibly increased - increased risk of adrenal suppression.
  Diuretics: enhanced hypokalaemic effects of acetazolamide, loop diuretics and thiazide diuretics.
  Vaccines: high dose corticosteroids can impair immune response to vaccines - avoid concomitant use with live vaccines.

• Stoffwechsel

  Hydrocortisone is metabolised in the liver and most body tissues to hydrogenated and degraded forms such as tetrahydrocortisone and tetrahydrocortisol. These are excreted in the urine, mainly conjugated as glucuronides, with a very small proportion of unchanged hydrocortisone.

Hydrocortison-21-(natriumsuccinat) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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