Desoxycorton

Bezeichnung:Desoxycorton

CAS-Nr64-85-7

Englisch Name:Desoxycorticosterone

CBNumberCB4314147

SummenformelC21H30O3

Molgewicht330.46

MOL-Datei64-85-7.mol

Synonyma

Desoxycorton

Desoxycorton physikalisch-chemischer Eigenschaften

Schmelzpunkt	138-144 °C
alpha	184 º (c=1, C2H5OH)
Siedepunkt	407.89°C (rough estimate)
Dichte	1.0998 (rough estimate)
Brechungsindex	1.5192 (estimate)
Flammpunkt	9℃
storage temp.	-20°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	12.98±0.10(Predicted)
Farbe	White to Pale Yellow
Optische Aktivität	+17822 (c 1.5, ethanol)
Wasserlöslichkeit	slightly soluble
Merck	13,2917
BRN	2062123
LogP	2.880
CAS Datenbank	64-85-7(CAS DataBase Reference)
NIST chemische Informationen	Deoxycorticosterone(64-85-7)
EPA chemische Informationen	Deoxycorticosterone (64-85-7)

Sicherheit

Kennzeichnung gefährlicher	Xn,T,F
R-Sätze:	40-48-39/23/24/25-23/24/25-11
S-Sätze:	22-24/25-45-36/37-16-7
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS-Nr.	HG0350000

Gefahreninformationscode (GHS)

Desoxycorticosterone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
R48:Gefahr ernster Gesundheitsschäden bei längerer Exposition.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white to creamy-white crystalline powder
Verwenden
A mineralocorticoid that occurs in adrenal cortex. It acts as a precursor to Aldosterone (A514700).
Verwenden
Antiinflammatory;Corticoide
Definition
ChEBI: A mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group.
Allgemeine Beschreibung
11-Deoxycorticosterone is a steroid hormone produced in the adrenal glands that acts as a precursor for the hormone aldosterone. Levels of 11-deoxycorticosterone are measured by LC-MS/MS to aid in diagnosing disorders of steroid synthesis, such as 11-hydroxylase deficiency and glucocorticoid responsive hyperaldosteronism. This Certified Spiking Solution^? is suitable for use as starting material inlinearity standards, calibrators, and controls for numerous LC-MS/MS applications in endocrinology, clinical chemistry, and neonatal screening.
Hazard
Toxic.
Mechanism of action
Desoxycorticosterone causes an increase in reabsorption of sodium ions and excretion of potassium ions from the renal tubules, which leads to increased tissue hydrophilicity. This facilitates an elevated volume of plasma and increased arterial pressure. Muscle tonicity and work capability are increased. It is used for an insufficiency of function of the adrenal cortex, myasthenia, asthenia, adynamia, and overall muscle weakness.
Synthese
Desoxycorticosterone, 21-hydroxypregn-4-en-3,20-dione acetate (27.2.6), is synthesized in a number of ways, the easiest of which being iodination of progesterone at C21 in the methyl group, and subsequent reaction of the resulting iodo-derivative 27.2.5 with potassium acetate, which leads to formation of the desired desoxycorticosterone in the form of the acetate (27.2.6) .
läuterung methode
Crystallise 11-deoxycorticosterone from diethyl ether. [Schindler et al. Helv Chim Acta 24 360 1941, Steiger & Reichstein Helv Chim Acta 20 1164 1937.]

Desoxycorticosterone Upstream-Materialien And Downstream Produkte

Desoxycorton Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

64-85-7, Desoxycorticosterone Verwandte Suche:

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