Desoxycortonacetat

Bezeichnung:Desoxycortonacetat

Englisch Name:Deoxycorticosterone acetate

CBNumberCB3462948

SummenformelC23H32O4

Molgewicht372.5

Synonyma

Desoxycortonacetat

Desoxycortonacetat physikalisch-chemischer Eigenschaften

Schmelzpunkt	157°C
alpha	D20 +168 to +176° (dioxane)
Siedepunkt	421.94°C (rough estimate)
Dichte	1.0415 (rough estimate)
Brechungsindex	175 ° (C=1, Dioxane)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	H₂O: insoluble
Farbe	White to Off-White
Wasserlöslichkeit	4mg/L(25 ºC)
Merck	2901
BRN	2570798
InChI	InChI=1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1
InChIKey	VPGRYOFKCNULNK-ACXQXYJUSA-N
SMILES	C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@H](C(=O)COC(C)=O)CC3)CC2
LogP	3.080
CAS Datenbank	56-47-3(CAS DataBase Reference)

Sicherheit

Gefahreninformationscode (GHS)

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Off-White Solid
Verwenden
Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
Verwenden
Adrenocortical/mineralocorticoid Steroid.
Definition
ChEBI: Deoxycorticosterone acetate is a corticosteroid hormone.
Trademarks
Doca (Organon); Percorten (Novartis) [Name previously used: Deoxycortone.].
Allgemeine Beschreibung
Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.
läuterung methode
11-Deoxycorticosterone acetate recrystallises from EtOH as needles or Me2CO/hexane, and sublimes at high vacuum. It is partly soluble in MeOH, Me2CO, Et2O and dioxane but insoluble in H2O. [Reichstein & Euw Helv Chim Acta 23 136 1940, Romo et al. J Am Chem Soc 79 5034 1957; NMR: Shoolery & Rogers J Am Chem Soc 80 5121 1959, Beilstein 8 IV 2195.]