Doxifluridin

Bezeichnung:Doxifluridin

CAS-Nr3094-09-5

Englisch Name:Doxifluridine

CBNumberCB4461786

SummenformelC9H11FN2O5

Molgewicht246.19

MOL-Datei3094-09-5.mol

Synonyma

Doxifluridin

Doxifluridin physikalisch-chemischer Eigenschaften

Schmelzpunkt	188-192 °C(lit.)
alpha	D25 +18.4° (c = 0.419 in water)
Dichte	1.3751 (estimate)
Brechungsindex	20 ° (C=1, H2O)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	7.4(at 25℃)
Farbe	White
Merck	14,3437
CAS Datenbank	3094-09-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-24/25
WGK Germany	2
RTECS-Nr.	YU7526000
Hazard Note	Irritant
HazardClass	IRRITANT, IRRITANT-HARMFUL
HS Code	29349990
Toxizität	LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu)

Gefahreninformationscode (GHS)

Doxifluridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers.
Chemische Eigenschaften
White Solid
Originator
Hoffmann-LaRoche (USA)
Verwenden
antineoplastic, pyrimidine antimetabolite
Verwenden
A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity
Verwenden
An antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine
Verwenden
5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.
Definition
ChEBI: A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluoro racil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.
Trademarks
Furtulon
Biochem/physiol Actions
Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.

Doxifluridine Upstream-Materialien And Downstream Produkte

Doxifluridin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

3094-09-5, Doxifluridine Verwandte Suche:

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