p-Toluenesulfonic acid monohydrate

Bezeichnung:p-Toluenesulfonic acid monohydrate

CAS-Nr6192-52-5

Englisch Name:p-Toluenesulfonic acid monohydrate

CBNumberCB3173385

SummenformelC7H10O4S

Molgewicht190.22

MOL-Datei6192-52-5.mol

p-Toluenesulfonic acid monohydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	96-99 °C(lit.)
Siedepunkt	140°C 20mm
Dichte	1,24 g/cm³
Dampfdichte	5.9 (vs air)
Brechungsindex	1,382-1,384
Flammpunkt	180 °C
storage temp.	Store at +5°C to +30°C.
Löslichkeit	H₂O: 0.1 g/mL, clear
Colour Index	42655
Aggregatzustand	Solid
Farbe	White to pink
PH	1 (650g/l, H2O, 20℃)(anhydrous substance)
Wasserlöslichkeit	soluble
Sensitive	Hygroscopic
Merck	14,9533
BRN	3568023
Stabilität	Stable. Incompatible with strong oxidizing agents, strong bases, most common metals. Protect from moisture.
InChIKey	KJIFKLIQANRMOU-UHFFFAOYSA-N
CAS Datenbank	6192-52-5(CAS DataBase Reference)
EPA chemische Informationen	Benzenesulfonic acid, 4-methyl-, monohydrate (6192-52-5)

Sicherheit

Kennzeichnung gefährlicher	Xi,C
R-Sätze:	36/37/38-34-37
S-Sätze:	26-37-45-36/37/39
RIDADR	UN 2585 8/PG 3
WGK Germany	-
RTECS-Nr.	XT6300000
F	3
Selbstentzündungstemperatur	600 °C
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29041000
Toxizität	LD50 orally in Rabbit: 2570 mg/kg

Gefahreninformationscode (GHS)

p-Toluenesulfonic acid monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37:Geeignete Schutzhandschuhe tragen.
Chemische Eigenschaften
White crystals
Verwenden
p-Toluenesulfonic acid monohydrate (p-TsOH·H₂O) may be used as a catalyst in the synthesis of the following:
- Unsymmetrical benzils.
- Highly substituted piperidines.
- 1,3,5-Trisubstituted benzenes by trimerization of alkynes.
- Triazoloquinazolinone and benzimidazoquinazolinone derivatives.
- 1,3,5-Trisubstituted pyrazoles derivatives.
- Selenated ketene dithioacetals.
Verwenden
Derivitizing agent.
Verwenden
p-Toluenesulfonic acid monohydrate is used as a catalyst in the synthesis of resveratrol, in oxane derivatives as an antimalarial agent, as substituted piperidine and unsymmetrical benzyl. It acts as a catalyst in the preparation of 1,3,5-trisubstituted pyrazoles derivatives, selenated ketene dithioacetals, triazoloquinazolinone and benzimidazoquinazolinone derivatives. It also serves as an intermediate in the esterification and in reductive amination reactions.
Allgemeine Beschreibung
p-Toluenesulfonic acid monohydrate, an oxonium salt, is an inexpensive and easy to handle organic catalyst used in organic synthesis. The study of its crystalline structure shows that it is monoclinic with P2₁/c space group. Its solubility in aqueous sulfuric acid solutions has been studied.
läuterung methode
Purify the acid by precipitation from a saturated solution at 0o by introducing HCl gas. It can also be crystallised from conc HCl, then crystallised from dilute HCl (charcoal) to remove benzenesulfonic acid. It has been crystallised from EtOH/water. Dry it in a vacuum desiccator over solid KOH and CaCl2. p-Toluenesulfonic acid can be dehydrated by azeotropic distillation with *benzene or by heating at 100o for 4hours under water-pump vacuum. The anhydrous acid can be crystallised from *benzene, CHCl3, ethyl acetate, anhydrous MeOH, or from acetone by adding a large excess of *benzene. It can also be dried under vacuum at 50o. The S-benzylisothiuronium salt has m 182o (from aqueous EtOH). [Beilstein 11 IV 241.]

p-Toluenesulfonic acid monohydrate Upstream-Materialien And Downstream Produkte

p-Toluenesulfonic acid monohydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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