Levonorgestrel

Bezeichnung:Levonorgestrel

CAS-Nr797-63-7

Englisch Name:Levonorgestrel

CBNumberCB7125746

SummenformelC21H28O2

Molgewicht312.45

MOL-Datei797-63-7.mol

Synonyma

Levonorgestrel

Levonorgestrel physikalisch-chemischer Eigenschaften

Schmelzpunkt	206°C
alpha	D20 -32.4° (c = 0.496 in CHCl3)
Siedepunkt	392.36°C (rough estimate)
Dichte	1.0697 (rough estimate)
Brechungsindex	1.4900 (estimate)
storage temp.	Sealed in dry,2-8°C
Löslichkeit	Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
Aggregatzustand	Solid
pka	13.09±0.40(Predicted)
Farbe	Crystals from MeOH/CHCl3
Wasserlöslichkeit	10mg/L(temperature not stated)
Merck	13,6736
BCS Class	1
InChI	InChI=1/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/s3
InChIKey	WWYNJERNGUHSAO-HABXDNTMNA-N
SMILES	C([C@]12CC[C@]3([H])[C@@]4([H])CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)C#C)C \|&1:1,4,6,16,18,22,r\|
CAS Datenbank	797-63-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,T
R-Sätze:	20/21/22-40-60
S-Sätze:	22-36
WGK Germany	3
RTECS-Nr.	JF8225000
HS Code	2937230000
Giftige Stoffe Daten	797-63-7(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Levonorgestrel Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Levonorgestrel exhibits some androgenic activity but no glucocortic oid or antimineraloc orticoid action. Levonorgestrel can be administered orally, transdermally (combined with estradiol and formulated as a 7-day patch), and for prolonged, continuous use, via an intrauterine device (IUD). The oral bioavailability of levonorgestrel is approximately 95%. From a protein binding pers pective, 48% of an oral dose is bound to SHBG, and 50% is bound to albumin. Levonorgestrel under goes metabolic reduction of its ketone and is hydroxylated.
Chemische Eigenschaften
White Solid
Originator
Ovrette,Wyeth,US,1968
Verwenden
progestin
Verwenden
D-(-)-Norgestrel is an emergency contraceptive. Levonorgestrel is safe, tolerated and effective in emergency contraception in woman. Norgestimate USP Related Compound A.
Definition
A synthetic steroid hormone used as an ingredient of oral contraceptives. Approved by FDA.
Manufacturing Process
To 0.7 gram of (+/-)-1,4-dihydro-17α-ethynyl-18-homo-oestradiol 3-methyl ether in 36 cc methanol was added 1.6 cc water and 2.4 cc concentrated hydrochloric acid. After standing at room temperature for 2 hours ether was added, and the washed and dried ethereal solution was evaporated, yielding a gum which was dissolved in 5 cc benzene and the solution absorbed on 50 grams of an activated fuller's earth. Elution with light petroleum containing increasing proportions of benzene gave a crystalline by-product: further elution with benzene containing a small proportion of ether gave a crystalline product which was recrystallized from ethyl acetate, yielding 0.11 gram of (+/-)-17α-ethynyl-18-homo-19-nortestosterone. MP 203° to 206°C.
Trademarks
Mirena (Berlex); Norplant (Wyeth); Plan B (Duramed).
Therapeutic Function
Progestin
Sicherheitsprofil
Human reproductive effects byingestion: menstrual cycle changes, fertility index.Questionable carcinogen with experimental neoplastigenicdata. When heated to decomposition it emits acrid smokeand irritating fumes.

Levonorgestrel Upstream-Materialien And Downstream Produkte

Levonorgestrel Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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