Cefotaxim-natrium Produkt Beschreibung

Cefotaxime sodium Struktur
64485-93-4
  • CAS-Nr.64485-93-4
  • Bezeichnung:Cefotaxim-natrium
  • Englisch Name:Cefotaxime sodium
  • Synonyma:Natrium-[6R-[6α,7β(Z)]]-3-(acetoxymethyl)-7-[(2-aminothiazol-4-yl)(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat;Cefotaxim-natrium
    ctx;hr756;Pretor;FIR-756;ru24756;Cefotax;Chemcef;Tolycar;CLAFORAN;Cefotaxime Na
  • CBNumber:CB2197478
  • Summenformel:C16H16N5NaO7S2
  • Molgewicht:477.45
  • MOL-Datei:64485-93-4.mol
Cefotaxim-natrium physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :162-163 C
  • alpha  :D20 +55±2° (c = 0.8 in water)
  • Brechungsindex :61 ° (C=1, H2O)
  • storage temp.  :Keep in dark place,Inert atmosphere,2-8°C
  • Löslichkeit :H2O: aqueous solutions of pH 4.3-6.2 are stable up to 3 weeks at 2-8 °C.soluble
  • Aggregatzustand :powder
  • Farbe :white to yellow
  • PH :pH(100g/l, 25℃) : 4.5~6.5
  • Wasserlöslichkeit :Soluble in water.
  • Merck  :14,1933
  • BRN  :5711411
  • Stabilität: :Stable. Incompatible with strong oxidizing agents.
Sicherheit

Cefotaxime sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
  • S-Sätze Betriebsanweisung: S22:Staub nicht einatmen.
    S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  • Chemische Eigenschaften White to pale yellow crystalline powder
  • Originator Claforan,Hoechst-Roussel,W. Germany,1980
  • Verwenden Broad spectrum third generation cephalosporin antibiotic. The name Cefotaxime applies to the isomer having a syn-methoxy imino group
  • Verwenden Cephalosporin antibacterial
  • Definition ChEBI: A cephalosporin organic sodium salt having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups.
  • Manufacturing Process A solution of 8 g of sodium bicarbonate in about 20 ml of ethanol was progressively added to 45.55 g of pure 3-acetoxymethyl-7-[2-(2-amino-4- thiazolyl)-2-methoxyiminoacetamido]-ceph-3-eme-4-carboxylic acid in 100 ml of distilled water and another 80 ml of ethanol and 4.5 g of activated carbon were added thereto. The mixture was stirred for 5 minutes and was filtered. The filter was rinsed with ethanol and the filtrate was evaporated to dryness under reduced pressure. The residue was taken up in 100 ml of ethanol and evaporated to dryness again. The residue was dissolved in 100 ml of methanol and the solution was poured into 2 l of acetone. The mixture was vigorously stirred and was vacuum filtered. The recovered product was rinsed with acetone and then ether and dried under reduced pressure to obtain 43.7 g of a white product which rehydrated in air to obtain a final weight of 45.2 g of sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2- methoxyiminoacetamido]-ceph-3-eme-4-carboxylate.
  • Trademarks Claforan (Sanofi Aventis).
  • Therapeutic Function Antibiotic
  • Clinical Use Cefotaxime (Claforan) was the first third-generationcephalosporin to be introduced. It possesses excellentbroad-spectrum activity against Gram-positive and Gramnegativeaerobic and anaerobic bacteria. It is more activethan moxalactam against Gram-positive organisms. Manyβ-lactamase–producing bacterial strains are sensitive to cefotaxime,including N. gonorrhoeae, Klebsiella spp., H. influenzae,S. aureus, and E. cloacae. Some, but not all,Pseudomonas strains are sensitive. Enterococci and Listeriamonocytogenes are resistant.
    The syn-isomer of cefotaxime is significantly more activethan the anti-isomer against β-lactamase–producing bacteria.This potency difference is, in part, because of greaterresistance of the syn-isomer to the action of β-lactamases.The higher affinity of the syn-isomer for PBPs, however,may also be a factor.
    Cefotaxime is metabolized in part to the less active desacetylmetabolite. Approximately 20% of the metaboliteand 25% of the parent drug are excreted in the urine. Theparent drug reaches the cerebrospinal fluid in sufficient concentrationto be effective in the treatment of meningitis.Solutions of cefotaxime sodium should be used within 24hours. If stored, they should be refrigerated. Refrigerated solutionsmaintain potency up to 10 days.
  • Veterinary Drugs and Treatments In the United States, there are no cefotaxime products approved for veterinary species but it has been used clinically in several species when an injectable 3rd generation cephalosporin may be indicated.
Cefotaxime sodium Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Cefotaxim-natrium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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64485-93-4, Cefotaxime sodium Verwandte Suche:
  • Cefotaxime:Claforan
  • FIR-756
  • (6R,7R)-7-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[(acetyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
  • (6R,7R)-7α-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
  • Cefotaxime sodium salt,Cefotaxim sodium salt
  • Cefotaxime Sodium (350 mg)
  • Cefotaxime Sodium (250 mg)J0C189901ug/mg(ai)
  • Cefotaxime Sodium (250 mg)
  • CefotaxiMe sodiuM API
  • CefotaxiMe sodiuM(Claforan
  • CefotaxiMe-Na-salt research grade
  • Cefotaxime for peak identification
  • AXIME SODIUM SALT
  • Cefotaxime Sodium for Injection
  • CEFOTAXIME NA-SALT
  • CEFOTAXIME SODIUM
  • CEFOTAXIME SODIUM SALT
  • CEFOTAXIM SODIUM SALT
  • CLAFORAN
  • ctx
  • Cefotaxime, Sodium Salt, High Purity, Cell Culture-Tested
  • (((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-,(6r-(6-alpha,7-beta
  • (z))),sodiumsalt
  • 2,0)oct-2-ene-2-carboxylicacid,3-((acetyloxy)methyl)-7-5-thia-1-azabicyclo(
  • 5-Thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylicacid,3-[(acetyloxy)methyl]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-,[6R-(6-.alpha.,7-.beta.(Z))],sodiumsalt
  • hr756
  • ru24756
  • sodium7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanate
  • sodium salt of 7-[2-(2-amino-4-thiazolyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 7 (Z)-(O-methyloxime), acetate (ester)
  • CEFOTAXIME SODIUM STERILE
  • sodium [6R-[6alpha,7beta(Z)]]-3-(acetoxymethyl)-7-[(2-aminothiazol-4-yl)(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • 7-[2-(2-AMINO-4-THIAZOLYL)GLYOXYLAMIDO]-3-(HYDROXYMETHYL)-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLATE 7(2)-(Z)-(O-METHYLOXIME) ACETATE, NA
  • [6R-[6alpha,7beta(z)]]-3-[(Acetyloxy)methyl]-[[(2-amine-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid monosodium salt
  • Cefotaxime sodium sterile USP/EP/JP
  • 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 3-(acetyloxy)methyl-7-(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetylamino-8-oxo-, monosodium salt, (6R,7R)-
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, monosodium salt, [6R-[6α,7β(Z)]]-
  • Cefotax
  • Chemcef
  • Pretor
  • Sodium cefotaxime
  • Tolycar
  • Cefotaxime Na
  • Cefotaxime free acid
  • Cefotaxime sodium sterile IP/Bp
  • CEFOTAXIME, SODIUM PLANT CELLCULTURE TES TED
  • CefotaximeSodiumSterileUsp24
  • (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt
  • [6R-[6α,7β(Z)]]-3-[(Acetyloxy)methyl]-7-[2-(2-amino-4-thiazolvl)-2-(methoxyimino)aeetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
  • Sodium salt (syn-isomer)
  • Cefotaxime (Drug Substance)
  • Ceftazidime Solution, 100ppm
  • Cefotaxime sodium salt, 92%, a third-generation cephalosporin antibiotic
  • Pharmaceutical Raw Material Cefotaxime Sodium Cas:64485-93-4
  • ([6R-[6alpha,7beta(z)]]-3-[(Acetyloxy)methyl]-[[(2-amine-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid monosodium salt
  • Cefotaxime sodium salt, ≥98%(HPLC)
  • sodium (6R,7R)-3-[(acetyloxy)methyl]-7-[2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • HR-756 (sodium salt)
  • Cefotaxime for peak identification CRS