3-Brom-2-oxopropionsure

Bezeichnung:3-Brom-2-oxopropionsure

CAS-Nr1113-59-3

Englisch Name:3-Bromopyruvic acid

CBNumberCB0380692

SummenformelC3H3BrO3

Molgewicht166.96

MOL-Datei1113-59-3.mol

Synonyma

3-Brom-2-oxopropionsure

3-Brom-2-oxopropionsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	77-82 °C
Siedepunkt	223.4±23.0 °C(Predicted)
Dichte	1.7314 (rough estimate)
Brechungsindex	1.4650 (estimate)
storage temp.	2-8°C
Löslichkeit	water: soluble1g/10 mL, clear, colorless
Aggregatzustand	White crystalline solid
pka	1.84±0.54(Predicted)
Farbe	White to Almost white
Wasserlöslichkeit	Soluble in water, dimethyl sulfoxide, ethyl acetate and water.
BRN	1746786
InChIKey	PRRZDZJYSJLDBS-UHFFFAOYSA-N
CAS Datenbank	1113-59-3(CAS DataBase Reference)
EPA chemische Informationen	Propanoic acid, 3-bromo-2-oxo- (1113-59-3)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34-20/21/22
S-Sätze:	26-36/37/39-45-27
RIDADR	UN 3261 8/PG 2
WGK Germany	3
RTECS-Nr.	UZ0840000
F	19-21
Hazard Note	Corrosive
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29183000

Gefahreninformationscode (GHS)

3-Bromopyruvic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
Chemische Eigenschaften
Off-white solid
Verwenden
3-Bromopyruvic acid is an intermediate of the fungicide thiabendazole. It was also used in the synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids.
Verwenden
Bromopyruvic Acid is a synthetic brominated derivative of pyruvic acid. Bromopyruvic Acid maybe a potential treatment for certain types of cancer as it has shown to be effective at eliminating aggress ive liver tumors.
Verwenden
Bromopyruvic acid is used as an affinity label for cysteine residues and a potential anti-cancer agent. It is involved in the synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids and substituted pyranones. It plays a vital role as a cross-linker between nucleic acids and proteins. It is used as an anticancer agent for lung tumors.
synthetische
Synthesis method of 3-bromopyruvic acid: add a little concentrated sulfuric acid and solvent dichloromethane to pyruvic acid in a reaction flask, add bromine dropwise for about 3.5h and stir, a white precipitate is produced, then continue to stir for 1h, dilute with cyclohexane and petroleum ether, then cool the reaction mixture to get crystals, filter, wash with petroleum ether and dry to get the finished product of 3-bromopyruvic acid.
Definition
ChEBI: 3-bromopyruvic acid is a 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is replaced by bromine. Synthetic brominated derivative and structural analog of pyruvic acid. Highly reactive alkylating agent. Anti-cancer drug It has a role as an alkylating agent and an antineoplastic agent. It is a 2-oxo monocarboxylic acid and an organobromine compound. It derives from a pyruvic acid. It is a conjugate acid of a 3-bromopyruvate.
Allgemeine Beschreibung
Bromopyruvic acid is an affinity label for cysteine residues?. It acts as cross-linker between nucleic acids and proteins. Kinetics of inactivation of pancreatic ribonuclease A by bromopyruvic acid has been investigated.
Lager
Store at -20°C
läuterung methode
Dry it by azeotropic distillation (with toluene), and then recrystallise it from dry CHCl3. Dry for 48hours at 20o (0.5 torr) over P2O5. Store it at 0o. [Labandiniere et al. J Org Chem 52 157 1987, Beilstein 3 III 1167.]

3-Bromopyruvic acid Upstream-Materialien And Downstream Produkte

3-Brom-2-oxopropionsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1113-59-3, 3-Bromopyruvic acid Verwandte Suche:

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