ChemicalBook CAS DataBase List 69657-51-8

69657-51-8

Name	Aciclovir sodium
CAS	69657-51-8
EINECS(EC#)	614-996-5
Molecular Formula	C8H12N5NaO3
MDL Number	MFCD01694138
Molecular Weight	249.21
MOL File	69657-51-8.mol

Chemical Properties

storage temp.	Keep in dark place,Inert atmosphere,Room temperature
InChI	InChI=1S/C8H11N5O3.Na.H/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14;;/h3,14H,1-2,4H2,(H3,9,11,12,15);;
InChIKey	NHOSLZCNAFQLKZ-UHFFFAOYSA-N
SMILES	C(N1C=NC2C(NC(N)=NC1=2)=O)OCCO.[NaH]

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338

Hazard Information

Chemical Properties

Acyclovir sodium is a white, crystalline powder with the molecular formula C8H12N5NaO3. The maximum solubility in water at 25°C exceeds 100 mg/mL. At physiologic pH, acyclovir sodium exists as the unionized form with a molecular weight of 225 and a maximum solubility in water at 37°C of 2.5 mg/mL. The pka's of acyclovir are 2.27 and 9.25.

Uses

Antiviral.

Indications

Acyclovir sodium is used in certain people to treat outbreaks of herpes simplex infection of the skin (such as on the genitals), mucous membrane areas (such as the mouth and nose), or the brain. It is also used in certain people to treat shingles infection. The viruses that cause these infections live in the body quietly until an outbreak occurs. Acyclovir does not cure these infections but it can speed the healing of the sores, decrease pain/itching/formation of new sores, and lower the risk of other problems from the virus (such as infection spreading to other parts of the body/organs, pain even after the sores heal).

Brand name

Zovirax (GlaxoSmithKline).

General Description

Acyclovir Sodium Injection is a synthetic nucleoside analogue active against herpes viruses. It is a sterile, aqueous solution for intravenous infusion, containing 50 mg acyclovir per mL in Water for Injection, USP. The concentration is equivalent to 54.9 mg of acyclovir sodium per mL in Water for Injection, USP. The sodium content is approximately 5.1 mg/mL. The pH range of the solution is 10.85 to 11.50. Further dilution of Acyclovir Sodium Injection in an appropriate intravenous solution must be performed before infusion.

Spectrum Detail

Supplier

HAINAN POLY PHARMCEUTICAL CO. LTD

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Wuhan Wsem Biological Co., Ltd.

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Simagchem Corp.

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Hubei Datong Bio-Chemical Technology Co.,Ltd

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Chizhou Kailong Import and Export Trade Co., Ltd.

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Raw material medicin reagent co.,Ltd

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Hubei widely chemical technology Co., Ltd.

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Amadis Chemical Company Limited

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Hubei widely chemical technology Co., Ltd.

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Wellman Pharmaceutical Group Limited

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AnHui HaiKang Pharmaceutical Co., Ltd.

Telephone86-0556-5800026 17709662922

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