144-55-8

Odorless white crystalline powder or lumps. Slightly alkaline (bitter) taste. pH (of freshly prepared 0.1 molar aqueous solution): 8.3 at 77°F. pH (of saturated solution): 8-9. Non-toxic.

SODIUM BICARBONATE(144-55-8) reacts exothermically with acids to generate non-toxic carbon dioxide gas. Decomposes when heated. Incompatible with acids, acidic salts (dopamine hydrochloride, pentazocine lactate, many alkaloidal salts) aspirin and bismuth salicylate.

Stable in dry air, but slowly decomposes in moist air. Moderately water soluble. Decomposes slowly in water (accelerated by agitation) .

Literature sources indicate that this chemical is noncombustible.

Sodium bicarbonate, which is the compound commonly called baking soda, exists as a white, odorless, crystalline solid. It occurs naturally as the mineral nahcolite, which derives its name from its chemical formula by replacing the “3” in NaHCO₃ with the ending “lite.” The world’s main source of nahcolite is the Piceance Creek Basin in western Colorado, which is part of the larger Green River formation. Sodium bicarbonate is extracted using solution mining by pumping hot water through injection wells to dissolve the nahcolite from the Eocene beds where it occurs 1,500 to 2,000 feet below the surface. The dissolved sodium bicarbonate is pumped to the surface where it is treated to recover NaHCO₃ from solution. Sodium bicarbonate can also be produced from the trona deposits, which is a source of sodium carbonates (see Sodium Carbonate).

Sodium bicarbonate occurs as an odorless, white, crystalline powder with a saline, slightly alkaline taste. The crystal structure is monoclinic prisms. Grades with different particle sizes, from a fine powder to free-flowing uniform granules, are commercially available.

Sodium bicarbonate, NaHC03, also known as sodium acid carbonate and baking soda, is a white water-soluble crystalline solid.It has an alkaline taste, loses carbon dioxide at 270°C (518 °F).and is used in food preparation. Sodium bicarbonate also finds use as a medicine,a butter preservative, in ceramics,and to prevent timber mold.

White crystalline powder or granules; monoclinic crystals; density 2.20 g/cm₃; decomposes around 50°C, begins to lose carbon dioxide; converts to sodium carbonate at 100°C; soluble in water, 10g/100 mL at 20°C; slowly decomposes to CO2 and Na2CO3 in aqueous solution at ambient temperature; decomposes to Na₂CO₃ in boiling water; aqueous solution slightly alkaline; pH of 0.1M solution at 25°C is about 8.3; insoluble in alcohol; decomposes in acids.

Baking soda: A white solid formed either by passing an excess of carbon dioxide through sodium carbonate or hydroxide solution, or by precipitation when cold concentrated solutions of sodium chloride and ammonium hydrogencarbonate are mixed. Sodium hydrogencarbonate decomposes on heating to give sodium carbonate, carbon dioxide, and water. With dilute acids, it yields carbon dioxide. It is used as a constituent of baking powder, in effervescent beverages, and in fire extinguishers. Its aqueous solutions are alkaline as a result of salt hydrolysis. Sodium hydrogencarbonate forms monoclinic crystals.

Most sodium bicarbonate in the United States is made synthetically by the reaction of sodium carbonate solution (Na2CO3) with carbon dioxide: Na₂CO_3(aq) + H₂O_(l) + CO_2(g) → 2NaHCO_3(aq). It can also be produced using the Solvay process, which uses ammonia, carbon dioxide, and salt to produce sodium bicarbonate according to the following series of reactions: 2NH_3(g) + CO_2(g) + H₂O_(l) → (NH₄)₂CO_3(aq)
(NH₄)₂CO_3(aq) + CO_2(g) + H₂O_(l) → 2NH₃HCO_3(aq)
NH₄HCO_3(aq) + NaCl_(aq) → NaHCO_3(s) + NH₄Cl_(aq).

Sodium bicarbonate is manufactured either by passing carbon dioxide into a cold saturated solution of sodium carbonate, or by the ammonia–soda (Solvay) process, in which first ammonia and then carbon dioxide is passed into a sodium chloride solution to precipitate sodium bicarbonate while the more soluble ammonium chloride remains in solution.

Neut (Abbott); Soda Mint (Lilly).

Nonflammable

Sodium bicarbonate is generally used in pharmaceutical formulations as a source of carbon dioxide in effervescent tablets and granules. It is also widely used to produce or maintain an alkaline pH in a preparation.
In effervescent tablets and granules, sodium bicarbonate is usually formulated with citric and/or tartaric acid; combinations of citric and tartaric acid are often preferred in formulations as citric acid alone produces a sticky mixture that is difficult to granulate, while if tartaric acid is used alone, granules lose firmness. When the tablets or granules come into contact with water, a chemical reaction occurs, carbon dioxide is evolved, and the product disintegrates. Melt granulation in a fluidized bed dryer has been suggested as a one-step method for the manufacture of effervescent granules composed of anhydrous citric acid and sodium bicarbonate, for subsequent compression into tablets.
Tablets may also be prepared with sodium bicarbonate alone since the acid of gastric fluid is sufficient to cause effervescence and disintegration. Sodium bicarbonate is also used in tablet formulations to buffer drug molecules that are weak acids, thereby increasing the rate of tablet dissolution and reducing gastric irritation.
The effects of tablet binders, such as polyethylene glycols, microcrystalline cellulose, silicified microcrystalline cellulose, pregelatinized starch, and povidone, on the physical and mechanical properties of sodium bicarbonate tablets have also been investigated.( 8,9) Additionally, sodium bicarbonate is used in solutions as a buffering agent for erythromycin, lidocaine, local anesthetic solutions, and total parenteral nutrition (TPN) solutions. In some parenteral formulations, e.g. niacin, sodium bicarbonate is used to produce a sodium salt of the active ingredient that has enhanced solubility. Sodium bicarbonate has also been used as a freeze-drying stabilizer and in toothpastes.
Recently, sodium bicarbonate has been used as a gas-forming agent in alginate raft systems and in floating, controlledrelease oral dosage forms for a range of drugs. Tablet formulations containing sodium bicarbonate have been shown to increase the absorption of paracetamol, and improve the stability of levothyroxine. Sodium bicarbonate has also been included in formulations of vaginal bioadhesive tablets and in carbon dioxide releasing suppositories.
Therapeutically, sodium bicarbonate may be used as an antacid, and as a source of the bicarbonate anion in the treatment of metabolic acidosis. Sodium bicarbonate may also be used as a component of oral rehydration salts and as a source of bicarbonate in dialysis fluids; it has also been suggested as a means of preventing radiocontrast-induced nephrotoxicity.
Sodium bicarbonate is used in food products as an alkali or as a leavening agent, e.g. baking soda.

Sodium bicarbonate is usually administered orally in order to regulate the serum pH. Imbalances of the plasma pH can be due to problems occurring in the kidneys such as renal tubular acidosis. Within the kidneys, blood is filtered before it passes through the tubular part of the nephrons where re-absorption or secretion of important salts and others takes place. In renal tubular acidosis, the kidneys either fail to filter or secrete acid ions (H+) from the plasma (secretion takes place in the distal tubule), or to recover bicarbonate ions (HCO3^-) from the filtrate (passive re-absorption takes place in the proximal tubule, active re-absorption at the distal tubule), which is necessary to balance the pH. In the view of this mode of action, the pharmaceutically active component of sodium bicarbonate is the bicarbonate anion, but the cation Na+ is responsible for solubility and compatibility.

Commonly used laboratory reagent

Sodium bicarbonate can be used to treat salicylate poisoning.

Metabolic acidosis
Alkalinisation of urine
Renoprotection against contrast media

Sodium bicarbonate is used in a number of pharmaceutical formulations including injections and ophthalmic, otic, topical, and oral preparations.
Sodium bicarbonate is metabolized to the sodium cation, which is eliminated from the body by renal excretion, and the bicarbonate anion, which becomes part of the body’s bicarbonate store. Any carbon dioxide formed is eliminated via the lungs. Administration of excessive amounts of sodium bicarbonate may thus disturb the body’s electrolyte balance, leading to metabolic alkalosis or possibly sodium overload with potentially serious consequences. The amount of sodium present in antacids and effervescent formulations has been sufficient to exacerbate chronic heart failure, especially in elderly patients.
Orally ingested sodium bicarbonate neutralizes gastric acid with the evolution of carbon dioxide and may cause stomach cramps and flatulence.
When used as an excipient, sodium bicarbonate is generally regarded as an essentially nontoxic and nonirritant material.
LD50 (mouse, oral): 3.36 g/kg
LD50 (rat, oral): 4.22 g/kg

Sodium bicarbonate is indicated to treat metabolic acidosis and alkalinize the urine. It is also used as adjunctive therapy in treating hypercalcemic or hyperkalemia crises.

Potentially hazardous interactions with other drugs
Increases lithium excretion.

Oral bicarbonate, such as sodium bicarbonate, neutralises gastric acid with the production of carbon dioxide. Bicarbonate not involved in that reaction is absorbed and in the absence of a deficit of bicarbonate in the plasma, bicarbonate ions are excreted in the urine, which is rendered alkaline, and there is an accompanying diuresis.

When heated to about 50℃, sodium bicarbonate begins to dissociate into carbon dioxide, sodium carbonate, and water; on heating to 250–300℃, for a short time, sodium bicarbonate is completely converted into anhydrous sodium carbonate. However, the process is both time- and temperature-dependent, with conversion 90% complete within 75 minutes at 93°C. The reaction proceeds via surface-controlled kinetics; when sodium bicarbonate crystals are heated for a short period of time, very fine needleshaped crystals of anhydrous sodium carbonate are formed on the sodium bicarbonate surface.
The effects of relative humidity and temperature on the moisture sorption and stability of sodium bicarbonate powder have been investigated. Sodium bicarbonate powder is stable below 76% relative humidity at 25℃ and below 48% relative humidity at 40℃. At 54% relative humidity, the degree of pyrolytic decarboxylation of sodium bicarbonate should not exceed 4.5% in order to avoid detrimental effects on stability.
At ambient temperatures, aqueous solutions slowly decompose with partial conversion into the carbonate; the decomposition is accelerated by agitation or heat. Aqueous solutions begin to break up into carbon dioxide and sodium carbonate at about 20°C, and completely on boiling.
Aqueous solutions of sodium bicarbonate may be sterilized by filtration or autoclaving. To minimize decomposition of sodium bicarbonate by decarboxylation on autoclaving, carbon dioxide is passed through the solution in its final container, which is then hermetically sealed and autoclaved. The sealed container should not be opened for at least 2 hours after it has returned to ambient temperature, to allow time for the complete reformation of the bicarbonate from the carbonate produced during the heating process. Aqueous solutions of sodium bicarbonate stored in glass containers may develop deposits of small glass particles. Sediments of calcium carbonate with traces of magnesium or other metal carbonates have been found in injections sterilized by autoclaving; these are due to impurities in the bicarbonate or to extraction of calcium and magnesium ions from the glass container. Sedimentation may be retarded by the inclusion of 0.01–0.02% disodium edetate.
Sodium bicarbonate is stable in dry air but slowly decomposes in moist air and should therefore be stored in a well-closed container in a cool, dry place.

Crystallise it from hot water (6mL/g). The solid should not be heated above 40o due to the formation of carbonate.

Sodium bicarbonate reacts with acids, acidic salts, and many alkaloidal salts, with the evolution of carbon dioxide. Sodium bicarbonate can also intensify the darkening of salicylates. In powder mixtures, atmospheric moisture or water of crystallization from another ingredient is sufficient for sodium bicarbonate to react with compounds such as boric acid or alum. In liquid mixtures containing bismuth subnitrate, sodium bicarbonate reacts with the acid formed by hydrolysis of the bismuth salt.
In solution, sodium bicarbonate has been reported to be incompatible with many drug substances such as ciprofloxacin, amiodarone, nicardipine, and levofloxacin.

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections; ophthalmic preparations; oral capsules, solutions, and tablets). Included in parenteral (intravenous infusions and injections) and nonparenteral medicines (chewing gums; ear drops; eye lotions; oral capsules, chewable tablets, effervescent powders, effervescent tablets, granules, soluble tablets, orodispersible tablets, and tablets; suppositories and suspensions) licensed in the UK.