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108-90-7

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Identification

Name
Chlorobenzene
CAS
108-90-7
Synonyms
AKOS BBS-00004382
BENZENE CHLORIDE
CHLOROBENZENE
CHLOROBENZENE, MONO
CHLOROBENZOL
CHLOROBEZENE, MONO
MONOCHLOROBENZENE
PHENYL CHLORIDE
U.N. 1134
1-Chlorobenzene
Abluton T30
benzene,chloro-
benzenemonochloride
caswellno183a
Chloorbenzeen
Chlorbenzen
Chlorbenzene
Chlorbenzol
Chlorobenzen
chloro-benzen
EINECS(EC#)
203-628-5
Molecular Formula
C6H5Cl
MDL Number
MFCD00000530
Molecular Weight
112.56
MOL File
108-90-7.mol

Chemical Properties

Appearance
Chlorobenzene is a colorless liquid with an almond-like odor. The Odor Threshold is between 0.1 and 3.0 μg/L. Also reported in the literature at 0.68 ppm and 0.741 ppm.
Appearance
colourless liquid
mp 
-45 °C
bp 
132 °C(lit.)

density 
1.1075
vapor density 
3.86 (vs air)

vapor pressure 
11.8 mm Hg ( 25 °C)

refractive index 
n20/D 1.524(lit.)

Fp 
75 °F

storage temp. 
0-6°C
Stability:
Stable. Incompatible with oxidizing agents. Flammable. Attacks some types of plastics, rubber and coatings.
Water Solubility 
0.4 g/L (20 ºC)
FreezingPoint 
-45.6℃
Merck 
14,2121
BRN 
605632
CAS DataBase Reference
108-90-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, chloro-(108-90-7)
EPA Substance Registry System
108-90-7(EPA Substance)

Safety Data

Hazard Codes 
Xn,N,T,F
Risk Statements 
R10:Flammable.
R20:Harmful by inhalation.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R40:Limited evidence of a carcinogenic effect.
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable.
Safety Statements 
S24/25:Avoid contact with skin and eyes .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR 
UN 1134 3/PG 3

WGK Germany 
2

RTECS 
CZ0175000


3-10
HazardClass 
3
PackingGroup 
III
HS Code 
29039100
Safety Profile
Suspected carcinogen. Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Mutation data reported. Strong narcotic with slight irritant qualities. Dichlorobenzols are strongly narcotic. Little is known of the effects of repeated exposures at lower concentrations, but it may cause hdney and liver damage. The industrial illnesses reported may possibly be due to nitrobenzol. Dangerous fire hazard when exposed to heat or flame. Moderate explosion hazard when exposed to heat or flame. Potentially explosive reaction with powdered sodium or phosphorus trichloride + sodtum. Violent reaction with AgClO4. Reacts vigorously with oxidizers. See also CHLORINATED HYDROCARBONS, AROMATIC. To fight fire, use foam, CO2, dry chemical, water to blanket fire. Associated with EPA Superfund sites
Hazardous Substances Data
108-90-7(Hazardous Substances Data)

Raw materials And Preparation Products

Raw materials
Hydrochloric acid-->Benzene-->Chlorine-->Aluminum oxide -->1,2-Dichlorobenzene-->Flow Cell-->p-Dichlorobenzene-->ANHYDROUS FERRIC CHLORIDE
Preparation Products
4-Chlorobenzenesulfonyl chloride-->2-TERT-BUTYLPYRIDINE-4-CARBONITRILE-->2-Chloroacetophenone-->Atrazine-->Phenyltrichlorosilane-->5-Bromothiophene-2-carbaldehyde-->5-CHLORO-3-METHYLBENZO[B]THIOPHENE-->6-BROMO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE-->3-CHLOROBENZO[B]THIOPHENE-2-CARBOXAMIDE-->Fluoxastrobin-->5-CHLOROBENZOTHIOPHENE-->5-DIMETHYLAMINO-THIOPHENE-2-CARBALDEHYDE-->3,4'-Dichlorodiphenyl ether-->METHYL 3-CHLOROBENZO[B]THIOPHENE-2-CARBOXYLATE-->Naphthol AS-D-->3-Hydroxy-N-(3-nitrophenyl)-2-naphthalenecarboxamide-->2,2'-(1,3,4-oxadiazole-2,5-diyl)bis[1-aminoanthraquinone] -->2-Bromo-4-nitroimidazole-->3-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID HYDRAZIDE-->2,5-Thiophenedicarboxylic acid-->ETHYL ALPHA-CHLOROPHENYLACETATE-->Baclofen-->4,4'-DDT-->3-Hydroxy-2-naphthoyl-ortho-phenetidide-->3-Hydroxy-N-naphthalen-1-ylnaphthalene-2-carboxamide-->3-CHLOROBENZO[B]THIOPHENE-2-CARBOXYLIC ACID-->2-Chloro-1,3-dinitrobenzene-->3-CHLOROBENZO[B]THIOPHENE-2-CARBONYL CHLORIDE-->2-THENOYLACETONITRILE-->2-Hydroxy-N-(4-methoxyphenyl)-11H-benzo[a]carbazole-3-carboxamide-->pigment yellow 155-->dimethyl 4-chloropyridine-2,6-dicarboxylate-->1-Benzyl-2-methyl-1H-imidazole-->3-(4-Chlorobenzoyl)propionic acid-->2-Chloroanthraquinone-->2-AMINO-5,6-DIMETHYLBENZOTHIAZOLE-->NAPHTHOL AS-LT-->3-Hydroxy-4'-methoxy-2-naphthanilide-->4,4'-Dichlorodiphenyl sulfone-->DICLOMEZINE

Hazard Information

General Description
A colorless to clear, yellowish liquid with a sweet almond-like odor. Flash point 84°F. Practically insoluble in water and somewhat denser than water (9.2 lb/gal). Vapors heavier than air. Used to make pesticides, dyes, and other chemicals.
Reactivity Profile
CHLOROBENZENE(108-90-7) undergoes a sometimes explosive reaction with powdered sodium or phosphorus trichloride + sodium. May react violently with dimethyl sulfoxide. Reacts vigorously with oxidizing agents. Attacks some forms of plastic, rubber and coatings. Forms a shock sensitive solvated salt with silver perchlorate. .
Air & Water Reactions
Highly flammable. Insoluble in water.
Hazard
A possible carcinogen. Avoid inhalation and skin contact. Moderate fire risk. Explosive limits 1.8–9.6%.
Health Hazard
Irritating to skin, eyes and mucous membranes. Repeated exposure of skin may cause dermatitis due to defatting action. Chronic inhalation of vapors or mist may result in damage to lungs, liver, and kidneys. Acute vapor exposures can cause symptoms ranging from coughing to transient anesthesia and central nervous system depression.
Potential Exposure
Chlorobenzene is used in the manufacture of aniline, phenol, and chloronitrobenzene; as an intermediate in the manufacture of dyestuffs and many pesticides, as a solvent; and emulsifier.
First aid
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended.
Shipping
UN1134 Chlorobenzene, Hazard Class: 3; Labels: 3-Flammable liquid.
Incompatibilities
Reacts violently with strong oxidizers; dimethyl sulfoxide; sodium powder; silver perchlorate; causing fire and explosion hazard. Attacks some plastics, rubber, and coatings. Decomposes on heating, producing phosgene and hydrogen chloride fumes.
Waste Disposal
Incineration, preferably after mixing with another combustible fuel; care must be exercised to assure complete combustion to prevent the formation of phosgene; an acid scrubber is necessary to remove the halo acids produced.

Material Safety Data Sheet(MSDS)

Questions And Answer

Description
Chlorobenzene is a monocyclic aromatic compound with one hydrogen atom on the benzene ring substituted with one chlorine. It is produced by chlorination of benzene in the liquid phase with a catalyst. Chlorobenzene is a colourless, flammable liquid with a sweet almond-like odor, at ambient temperature with a relatively high vapour pressure, moderate octanol-water partition coefficient (log 2.8) and moderate to low water solubility (497.9 mg/L @ 25℃). Chlorobenzene has a high solubility in nonpolar solvents, however, it is almost insoluble in water. Technical grade Chlorobenzene is typically 99% pure with < 0.05% benzene and < 0.1% dichlorobenzenes as contaminants. It is a common solvent and a widely used intermediate in the manufacture of other chemicals. Rhodococcus phenolicus is a bacterium species able to degrade chlorobenzene as sole carbon sources.
Uses
  1. Chlorobenzene is used primarily as raw material for the synthesis of o- and p-nitrochlorobenzene and 2,4-dinitrochlorobenzene.Important quantitative chemical conversions other than the production of nitrochlorobenzenes are the production of diphenyl oxide and diphenyldichlorosilane.
  2. Chlorobenzene is mainly used as raw material for the synthesis of chemicals including triphenylphosphine (catalyst for organic synthesis), phenylsilane, and thiophenol (pesticide and pharmaceutical intermediate). It is also used as raw material for the synthesis of solvent for organic synthesis reactions including methylenediphenyldiisocyanate, urethane raw material, agricultural adjuvants, paint and ink, and cleaning solvent for electronics.
  3. manufacture of phenol, aniline, DDT; solvent for paints; heat transfer medium.
  4. Chlorobenzene is used as a process solvent in the production of isocyanates such as MDI and TDI and as a solvent in various crop protection formulations. It is further used as a solvent in condensation reactions in the dyes industry.
  5. Chlorobenzene is a basic substance used in chemical syntheses with 95% of the quantity used converted in closed systems to intermediate and final products.
  6. It is used as a process solvent in the manufacture of three indigoid dyes and pigments. All the pigments and dyes are thioindigoid colors.
  7. Chlorobenzene is an example of haloarenes which is formed by mono substitution of benzene ring. When chlorobenzene is fused with sodium hydroxide at 623K and 320 atm sodium phenoxide is produced. Finally, sodium phenoxide on acidification gives phenols.
    Preparation of phenols from Chlorobenzene

Toxicity
The toxic effects of chlorobenzene on humans were exhaustion, nausea, lethargy, headache and irritation to the upper respiratory tract and eye. Contact of chlorobenzene with the skin induced irritation. No reports were obtained on sensitization by chlorobenzene in this investigation.
The oral LD50 values of chlorobenzene were 1,445 mg/kg in mice, 1,427 to 3,400 mg/kg in rats and 2,250 to 2,830 mg/kg in rabbits. The LC50s following 6-hr inhalation exposure were 1,889 ppm in mice and 2,968 ppm in rats.

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