Изопропиламин
- английское имяIsopropylamine
- CAS №75-31-0
- CBNumberCB8854223
- ФормулаC3H9N
- мольный вес59.11
- EINECS200-860-9
- номер MDLMFCD00008082
- файл Mol75-31-0.mol
химическое свойство
| Температура плавления | -101 °C |
| Температура кипения | 32-35 °C 33-34 °C (lit.) |
| плотность | 0.688 g/mL at 20 °C (lit.) |
| плотность пара | 2.04 (vs air) |
| давление пара | 9.2 psi ( 20 °C) |
| FEMA | 4238 | ISOPROPYLAMINE |
| показатель преломления | n |
| Fp | −26 °F |
| температура хранения | 2-8°C |
| растворимость | 1000g/l |
| форма | Crystalline Powder, Needles or Crystals |
| пка | 10.63(at 25℃) |
| цвет | APHA: ≤50 |
| Запах | Strong ammoniacal; pungent, irritating, typical amine. |
| РН | 13 (700g/l, H2O, 20℃) |
| Пределы взрываемости | 2-10.4%(V) |
| Порог?обнаружения?запаха? | 0.025ppm |
| Odor Type | fishy |
| Растворимость в воде | soluble |
| Чувствительный | Air Sensitive |
| Номер JECFA | 1581 |
| Мерк | 14,5209 |
| БРН | 605259 |
| Пределы воздействия | TLV-TWA 5 ppm (～12 mg/m3) (ACGIH, MSHA, and OSHA); TLV-STEL 10 ppm(～24 mg/m3) (ACGIH); IDLH 4000 ppm (NIOSH). |
| Диэлектрическая постоянная | 5.5（20℃） |
| Стабильность | Stable. Extremely flammable - note low boiling point and low flash point. Readily forms explosive mixtures with air. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, perchloryl fluoride. |
| LogP | 0.21 |
| Вещества, добавляемые в пищу (ранее EAFUS) | ISOPROPYLAMINE |
| Справочник по базе данных CAS | 75-31-0(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 3-5 |
| FDA UNII | P8W26T4MTD |
| Справочник по химии NIST | 2-Propanamine(75-31-0) |
| Система регистрации веществ EPA | Isopropylamine (75-31-0) |
больше
| Коды опасности | F+,Xi,T | |||||||||
| Заявления о рисках | 12-36/37/38-37-35-25-20/21 | |||||||||
| Заявления о безопасности | 16-26-29-45-36/37/39 | |||||||||
| РИДАДР | UN 1221 3/PG 1 | |||||||||
| WGK Германия | 1 | |||||||||
| RTECS | NT8400000 | |||||||||
| F | 34 | |||||||||
| Температура самовоспламенения | 755 °F | |||||||||
| TSCA | Yes | |||||||||
| кода HS | 2921 19 99 | |||||||||
| Класс опасности | 3 | |||||||||
| Группа упаковки | I | |||||||||
| Банк данных об опасных веществах | 75-31-0(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 orally in rats: 820 mg/kg (Smyth) | |||||||||
| ИДЛА | 750 ppm | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H335：Может вызывать раздражение верхних дыхательных путей.
H301+H311+H331：Токсично при проглатывании, при контакте с кожей или при вдыхании.
H314：При попадании на кожу и в глаза вызывает химические ожоги.
H224：Чрезвычайно легко воспламеняющаяся жидкость. Пары образуют с воздухом взрывоопасные смеси.
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оператор предупредительных мер
P210：Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P233：Держать в плотно закрытой/герметичной таре.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P303+P361+P353：ПРИ ПОПАДАНИИ НА КОЖУ (или волосы): Снять/удалить немедленно всю загрязненную одежду. Промыть кожу водой.
P304+P340+P310：ПРИ ВДЫХАНИИ: Свежий воздух, покой. Немедленно обратиться за медицинской помощью.
P305+P351+P338：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
P403+P233：Хранить в хорошо вентилируемом месте в плотно закрытой/герметичной таре.
Изопропиламин химические свойства, назначение, производство
Описание
Isopropylamine (propan-2-amine, IUPAC) is a colorless, volatile liquid. It is highly flammable, with a flammable range of 2%–10.4% in air. Boiling point is 93°F (33°C), flash point is ?15°F (?26°C), and ignition temperature is 756°F (402°C).It is miscible with water, with a specific gravity of 0.69, which is lighter than water. Vapor density is 2.04, which is heavier than air. In addition to flammability, isopropylamine is a strong irritant to tissue and has a TLV of 5 ppm in air. The four-digit UN identification number is 1221. The NFPA 704 designation for isopropylamine is health 3, flammability 4, and reactivity 0. Primary uses for isopropylamine are pharmaceuticals, dyes, insecticides, and as a dehairing agent.
Химические свойства
Isopropylamine is a colorless, flammable liquid. Isopropylamine is miscible with water, alcohol, and ether.The odor threshold reportedly ranges from 0.21 to 0.70 ppm; the pungent, ammoniacal odor becomes irritating at 24mg/m3 (110).Физические свойства
Colorless liquid with a penetrating, ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 500 μg/m3 (210 ppbv) and 1.7 mg/m3 (700 ppbv), respectively (Hellman and Small, 1974). An odor threshold concentration of 25 ppbv was reported by Nagata and Takeuchi (1990).Вхождение
Not reported found in natuИспользование
Isopropylamine is used as a dehairing agentand as an intermediate in the preparation ofmany organics.Методы производства
Isopropylamine can be produced from the corresponding alcohol by reacting with ammonia in the presence of a dehydrating catalyst, or from the chloride by reacting with ammonia under pressure. It is also reported that this amine can be produced from acetone and ammonia or from the acetone oxime (HSDB 1989).Определение
ChEBI: A member of the class of alkylamines that is propane carrying an amino group at position 2.Общее описание
A clear colorless liquid with an ammonia-like odor. Flash point -35°F. Boiling point 90°F. Less dense than water Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used as a solvent and to make other chemicals.Реакции воздуха и воды
Highly flammable. Water soluble.Профиль реактивности
Isopropylamine is a colorless, alkaline liquid, very volatile, moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition Isopropylamine emits toxic fumes of oxides of nitrogen [M. K.]. A mixture of Isopropylamine and perchloryl fluoride resulted in an uncontrolled oxidation and/or explosion, [J. Org. Chem., 1980, 45, 4036]. The reaction of 1-chloro-2,3-epoxypropane and the amine and most probably other nitrogen bases, yields a violent exotherm, [Chem. & Ind., 1971, 994].Опасность
Highly flammable, dangerous fire risk. Strong irritant to tissue.Угроза здоровью
Isopropylamine is a strong irritant to theeyes, skin, and respiratory system. A shortexposure to 10–20 ppm can cause irritationof the nose and throat in humans (Procturand Hughes 1978). Prolonged exposure tohigh concentrations may lead to pulmonaryedema. Skin contact can cause dermatitisand skin burns. Exposure to 8000 ppm for4 hours was lethal to rats.LD50 value, oral (mice): 2200 mg/kg.
Химическая реактивность
Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.Промышленное использование
Isopropylamine can be used as a dehairing agent and as a solvent. It also finds use as an intermediate in the production of insecticides, herbicides and bactericides and in the production of pharmaceuticals, dyes and rubber accelerators (HSDB 1989).Экологическая судьба
Photolytic. Low et al. (1991) reported that the photooxidation of aqueous primary amine solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium and nitrate ions.Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987). Forms water-soluble salts with acids.
Метаболизм
One would expect isopropylamine to be readily absorbed from the gut and respiratory tract. Shorter chain aliphatic amines such as isopropylamine also are efficiently absorbed through the skin (Beard and Noe 1981). When administered intravenously, isopropylamine distributed rapidly into tissue compartments with tissue/plasma ratios ranging from 1.8 in the atrium to 16.7 in the renal medulla (Privitera et al 1982). During the elimination phase, a half-life of 146 min was observed in plasma. There do not appear to be any definitive metabolic studies with this compound, however through a comparison with other substrates, one might expect oxidation to acetone and ammonia through the action of monoamine oxidase (Tipton 1980).Изопропиламин запасные части и сырье
сырьё
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запасной предмет
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