Диизопропиламин
- английское имяDiisopropylamine
- CAS №108-18-9
- CBNumberCB5852738
- ФормулаC6H15N
- мольный вес101.19
- EINECS203-558-5
- номер MDLMFCD00008862
- файл Mol108-18-9.mol
химическое свойство
| Температура плавления | -61 °C (lit.) |
| Температура кипения | 84 °C (lit.) |
| плотность | 0.722 g/mL at 25 °C (lit.) |
| плотность пара | 3.5 (vs air) |
| давление пара | 50 mm Hg ( 20 °C) |
| показатель преломления | n |
| Fp | 1.4 °F |
| температура хранения | Store below +30°C. |
| растворимость | 100 g/L (20°C) |
| пка | 11.05(at 25℃) |
| форма | Liquid |
| цвет | Clear colorless |
| Запах | Amine. |
| РН | 11.8 (6g/l, H2O, 20℃) |
| Пределы взрываемости | 1.1-7.1%(V) |
| Растворимость в воде | 100 g/L (20 ºC) |
| Мерк | 14,3196 |
| БРН | 605284 |
| Пределы воздействия | NIOSH REL: TWA 5 ppm (20 mg/m3), IDLH 200 ppm; OSHA PEL: TWA 5 ppm; ACGIH TLV: TWA 5 ppm (adopted). |
| Диэлектрическая постоянная | 3.04 |
| Стабильность | Stable. Flammable. Incompatible with strong oxidizing agents. May react violently with strong acids or oxidizers. Air sensitive. |
| ИнЧИКей | UAOMVDZJSHZZME-UHFFFAOYSA-N |
| LogP | 0.4 at 20℃ |
| Справочник по базе данных CAS | 108-18-9(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 2-5 |
| FDA UNII | BR9JLI40NO |
| Справочник по химии NIST | 2-Propanamine, N-(1-methylethyl)-(108-18-9) |
| Система регистрации веществ EPA | Diisopropylamine (108-18-9) |
больше
| Коды опасности | F,C | |||||||||
| Заявления о рисках | 11-20/22-34 | |||||||||
| Заявления о безопасности | 16-26-36/37/39-45 | |||||||||
| РИДАДР | UN 1158 3/PG 2 | |||||||||
| OEB | A | |||||||||
| OEL | TWA: 5 ppm (20 mg/m3) [skin] | |||||||||
| WGK Германия | 2 | |||||||||
| RTECS | IM4025000 | |||||||||
| Температура самовоспламенения | 599 °F | |||||||||
| Примечание об опасности | Highly Flammable/Corrosive/Harmful | |||||||||
| TSCA | Yes | |||||||||
| кода HS | 2921 19 99 | |||||||||
| Класс опасности | 3 | |||||||||
| Группа упаковки | II | |||||||||
| Банк данных об опасных веществах | 108-18-9(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 orally in rats: 0.77 g/kg (Smyth) | |||||||||
| ИДЛА | 200 ppm | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H335：Может вызывать раздражение верхних дыхательных путей.
H302：Вредно при проглатывании.
H314：При попадании на кожу и в глаза вызывает химические ожоги.
H225：Легковоспламеняющаяся жидкость. Пары образуют с воздухом взрывоопасные смеси.
H331：Токсично при вдыхании.
H412：Вредно для водных организмов с долгосрочными последствиями.
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оператор предупредительных мер
P210：Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P273：Избегать попадания в окружающую среду.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P303+P361+P353：ПРИ ПОПАДАНИИ НА КОЖУ (или волосы): Снять/удалить немедленно всю загрязненную одежду. Промыть кожу водой.
P304+P340+P310：ПРИ ВДЫХАНИИ: Свежий воздух, покой. Немедленно обратиться за медицинской помощью.
P305+P351+P338：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
Диизопропиламин химические свойства, назначение, производство
Описание
Diisopropylamine is a secondary amine and is a colorless liquid at room temperature with a fishy, ammonia-like odor. It is used as a chemical intermediate, and catalyst for the synthesis of pesticides and pharmaceuticals. Diisopropylamine is associated with tobacco either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. Synonyms for diisopropylamine include DIPA, and N-(1-methylethyl)-2- propanamine.Химические свойства
Diisopropylamine is a flammable, strongly alkaline Colorless liquid. Diisopropylamine is soluble in water and alcohol. The odor threshold ranges from 0.017 to 4.2 ppm; the fishlike odor becomes irritating at 100 mg/m3.Физические свойства
Colorless liquid with an ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 50 μg/m3 (130 ppbv) and 190 μg/m3 (380 ppbv), respectively (Hellman and Small, 1974).прикладной
Diisopropylamine is used as a solvent and in the chemical synthesis of dyes, pharmaceuticals, and other organic syntheses. It used to synthesize diisopropylamine methyl urea (DMU), N,N-diisopropyl quinoline-2-carboxamide, 3-N-sulfonylamidine coumarins and N-chloroamine, an intermediate to generate amides.Общее описание
Diisopropylamine appears as a clear colorless liquid with an ammonia-like odor. Flash point 30°F. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used to make other chemicals.Реакции воздуха и воды
Highly flammable. Soluble in water. Sensitive to heat and air.Профиль реактивности
Diisopropylamine can react violently with oxidizing agents and strong acids. Readily eutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.Угроза здоровью
Permitted levels of diisopropylamine should not cause adverse health and welfare effects. Acute inhalation exposure to diisopropylamine can cause sore throat, cough, burning sensation and shortness of breath. Adverse effects occur mainly in the upper respiratory tract, although after chronic exposure. There is no definitive evidence that diisopropylamine causes cancer so a chronic cancer value was not developed. Diisopropylamine has not been classified as causing cancer by the International Agency for Research on Cancer, the United States Environmental Protection Agency, the American Conference of Industrial Hygienists, or the National Toxicology Program.Химическая реактивность
Reactivity with Water No reaction; Reactivity with Common Materials: May attack some forms of plastics; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.Промышленное использование
Diisopropylamine is used as a catalyst and as a stabilizer for mesityl oxide (HSDB 1989). It is also used as an intermediate in the synthesis of dyes, pharmaceuticals and pesticides (e.g. Diallate, Fenamiphos and Triallate).Профиль безопасности
Moderately toxic by ingestion and subcutaneous routes. Mildly toxic by inhalation. Mutation data reported. A skin and severe eye irritant. Inhalation of fumes can cause pulmonary edema. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use alcohol foam,foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx See also AMINES.Экологическая судьба
Photolytic. Low et al. (1991) reported that the photooxidation of aqueous secondary amine solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium and nitrate ions.Chemical/Physical. Reacts with acids forming water-soluble salts.
Метаболизм
Little, if any investigation of the metabolism of short-chain aliphatic amines has been reported and the best that can be done is to suggest some possible metabolic routes. For example the flavin monooxygenase system could produce the hydroxylamine through N-hydroxylation catalyzed by the flavin monooxygenase system (Ziegler 1988). N-hydroxylation can also be induced with the cytochrome P-450 system as can N-dealkylation reactions (Lindeke and Cho 1982). More definitive analysis must await experimental studies.Методы очистки
Distil the amine from NaOH, or reflux it three minutes over Na wire or NaH, and distil it into a dry receiver under N2. [Beilstein 4 H 154, 4 I 369, 4 II 630, 4 III 274, 4 IV 510.]Диизопропиламин запасные части и сырье
сырьё
запасной предмет
- 2-Fluoro-6-formylpyridine
- (4-пиридил) ацетон
- 4-(трифторметил)никотиновая кислота
- 1 - (3,4-дихлорбензил) пиперазин
- 2-methylhexanoic acid
- 1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID
- Triallate
- Дибензил диизопропилфосфорамид
- Бис(диизопропиламино)хлорфосфин
- 2-Хлор-4-йодпиридин-3-карбоксальдегида
- 3,4-DIBROMO-5-HYDROXY-5H-FURAN-2-ONE
- 3-бром-4-пиридинкарбоксальдегид
- 2-фтор-5-йодбензальдегида
- 5-AMINO-2-METHOXY-3-PICOLINE
- DIALLATE
- 2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol
- 1-Boc-4-methylpiperidine-4-carboxylic acid
- Eflornithine
- 2,5-DICHLORO-4-FORMYLPYRIDINE
- 1-Boc-piperazine acetate
- 3,4-Dichloropyridine
- 3-амино-5-фенилпиразол
- 2-диизопропиламиноэтанол
- 2-Bromo-6-fluorobenzoic acid
- 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
- N,N-ДИИЗОПРОПИЛБЕНЗОТИАЗОЛ-2-СУЛЬФЕНАМИД
- 1,2-бис(4-пиридил)этан
- 4-BROMO-5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE
- 1-(2-ИЗОЦИАНОЭТИЛ)-4-МЕТИЛПИПЕРАЗИН
- 2-Хлор-6-(трифторметил) никотиновая кислота
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