General Description
A clear colorless liquid with an ammonia-like odor. Flash point-35°F. Boiling point 90°F. Less dense than water Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used as a solvent and to make other chemicals.
Reactivity Profile
ISOPROPYLAMINE(75-31-0) is a colorless, alkaline liquid, very volatile, moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition ISOPROPYLAMINE(75-31-0) emits toxic fumes of oxides of nitrogen [M. K.]. A mixture of ISOPROPYLAMINE(75-31-0) and perchloryl fluoride resulted in an uncontrolled oxidation and/or explosion, [J. Org. Chem., 1980, 45, 4036]. The reaction of 1-chloro-2,3-epoxypropane and the amine and most probably other nitrogen bases, yields a violent exotherm, [Chem. & Ind., 1971, 994].
Air & Water Reactions
Highly flammable. Water soluble.
Hazard
Highly flammable, dangerous fire risk.
Strong irritant to tissue.
Health Hazard
Inhalation causes nose and throat irritation, severe coughing, and chest pain due to irritation of air passages; can cause lung edema and loss of consciousness. Ingestion causes nausea, salivation and severe irritation of mouth and stomach. Contact with eyes causes severe irritation and possible edema of the cornea. Contact with skin causes severe irritation.
Description
Isopropylamine (propan-2-amine, IUPAC) is a colorless, volatile liquid. It is highly flammable, with a flammable range of 2%–10.4% in air. Boiling point is 93°F (33°C), flash point is ?15°F (?26°C), and ignition temperature is 756°F (402°C).
It is miscible with water, with a specific gravity of 0.69, which is lighter than water. Vapor density is 2.04, which is heavier than air. In addition to flammability, isopropylamine is a strong irritant to tissue and has a TLV of 5 ppm in air. The four-digit UN identification number is 1221. The NFPA 704 designation for isopropylamine is health 3, flammability 4, and reactivity 0. Primary uses for isopropylamine are pharmaceuticals, dyes, insecticides, and as a dehairing agent.
Chemical Properties
Isopropylamine is a colorless, flammable liquid. Isopropylamine is miscible
with water, alcohol, and ether.The odor threshold reportedly ranges from 0.21 to 0.70 ppm;
the pungent, ammoniacal odor becomes irritating at 24mg/m3
(110).
Physical properties
Colorless liquid with a penetrating, ammonia-like odor. Experimentally determined detection and
recognition odor threshold concentrations were 500 μg/m3 (210 ppbv) and 1.7 mg/m3 (700 ppbv),
respectively (Hellman and Small, 1974). An odor threshold concentration of 25 ppbv was reported
by Nagata and Takeuchi (1990).
Occurrence
Not reported found in natu
Definition
ChEBI: A member of the class of alkylamines that is propane carrying an amino group at position 2.
Production Methods
Isopropylamine can be produced from the corresponding alcohol by reacting with
ammonia in the presence of a dehydrating catalyst, or from the chloride by
reacting with ammonia under pressure. It is also reported that this amine can be
produced from acetone and ammonia or from the acetone oxime (HSDB 1989).
Aroma threshold values
High strength odor; fishy type; recommend smelling in a 0.10% solution or less.
Chemical Reactivity
Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Industrial uses
Isopropylamine can be used as a dehairing agent and as a solvent. It also finds use
as an intermediate in the production of insecticides, herbicides and bactericides
and in the production of pharmaceuticals, dyes and rubber accelerators (HSDB
1989).
Environmental Fate
Photolytic. Low et al. (1991) reported that the photooxidation of aqueous primary amine
solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium
and nitrate ions.
Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and
Lewis, 1987). Forms water-soluble salts with acids.
Metabolism
One would expect isopropylamine to be readily absorbed from the gut and
respiratory tract. Shorter chain aliphatic amines such as isopropylamine also are
efficiently absorbed through the skin (Beard and Noe 1981). When administered
intravenously, isopropylamine distributed rapidly into tissue compartments with
tissue/plasma ratios ranging from 1.8 in the atrium to 16.7 in the renal medulla
(Privitera et al 1982). During the elimination phase, a half-life of 146 min was
observed in plasma. There do not appear to be any definitive metabolic studies
with this compound, however through a comparison with other substrates, one
might expect oxidation to acetone and ammonia through the action of monoamine
oxidase (Tipton 1980).