Линолиевая кислота

Описание

Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA). It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay. Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.

Химические свойства

Linoleic acid occurs as a colorless to light-yellow-colored oil.

Использование

linoleic acid (vitamin F) is also known as omega-6. An emulsifier, it is also cleansing, emollient, and skin conditioning. Some formulations incorporate it as a surfactant. Linoleic acid prevents dryness and roughness. A deficiency of linoleic acid in the skin is associated with symptoms similar to those characterizing eczema, psoriasis, and a generally poor skin condition. In numerous laboratory studies where a linoleic acid deficiency was induced, a topical application of linoleic acid in its free or esterified form quickly reversed this condition. In addition, there is some evidence in laboratory tests that linoleic acid may inhibit melanin production by decreasing tyrosinase activity and suppressing melanin polymer formation within melanosomes. Linoleic acid is an essential fatty acid found in a variety of plant oils, including soybean and sunflower.

Определение

linoleic acid: A liquid polyunsaturatedfatty acid with two doublebonds, CH₃(CH₂)₄CH:CHCH_2-CH:CH(CH₂)₇COOH.Linoleic acid isabundant in plant fats and oils,e.g.linseed oil, groundnut oil,and soyabeanoil.It is an essential fatty acid.

Методы производства

Linoleic acid is obtained by extraction from various vegetable oils such as safflower oil.

Общее описание

Colorless to straw colored liquid. A polyunsaturated fatty acid essential to human diet.

Реакции воздуха и воды

Sensitive to air and light. . Oxidizes across carbon double bonds

Профиль реактивности

Linoleic acid reacts to neutralize bases. May react vigorously with oxidizing agents. May react exothermically with reducing agents to release hydrogen gas.

Пожароопасность

Flash point data for Linoleic acid are not available. Linoleic acid is probably combustible.

Фармацевтические приложения

Linoleic acid is used in topical transdermal formulations, in oral formulations as an absorption enhancer, and in topical cosmetic formulations as an emulsifying agent, and in aqueous microemulsions.It is also used in parenteral emulsions for total parenteral nutrition and in nonprescription oral dietary supplements.

Безопасность

Linoleic acid is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic material. On exposure to the eyes, skin, and mucous membranes, linoleic acid can cause mild irritation.

хранилище

Linoleic acid is sensitive to air, light, moisture, and heat. It should be stored in a tightly sealed container under an inert atmosphere and refrigerated.

Несовместимости

Linoleic acid is incompatible with bases, strong oxidizing agents, and reducing agents.

Регуляторный статус

GRAS listed. Approved for use in foods in Europe and the USA.