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• Linoleic acid and its function

  Linoleic acid is unsaturated omega-6 fatty acid usually found in corn, safflower, and sunflower oils. As it cannot be synthesized in vivo and has a defined metabolic significance, Linoleic acid is accepted as an essentical nutrient. Linolenic acid gives rise to arachidonic acid, which is the major precursor of a series of bioactive metabolites called eicosanoids, which regulate physiological processes in large scale such as prostaglandins, thromboxane A2, prostacyclin I2, leukotriene B4 and anandamide providing the body anti-inflammatory, moisturizing and healing support.
  In 1930, Scientist reported that the rats exhibited scaly skin lesions, impaired growth, tail necrosis, and renal degeneration by the lack of linoleic acid, and the return of this fatty acid to the animal’s diet cured the lesions. Administration of only 1 to 2% of dietary calories in the form of linoleic acid will support normal growth and development and prevent the clinical appearance of essential fatty acid deficiency (EFAD). Linoleic acid deficiency possibly happens in infants fed skimmed milk, in patients with chronic fat malabsorption, and in those undergoing total parenteral nutrition, which will cause poor growth and development in infants and dermatitis in adults. ;

• Brief Introduction

  Linoleic acid is named cis-9, 12-octadecadienoic acid, can also use △ to denote double bond, thus being named △ 9, 12-octadecadienoic acid. Alternatively, it can be simply expressed as 9C, 12C-18: 2 or C18: 2.
  Linoleic acid in foods is important for human body to maintain many physiological functions such as the synthesis of phospholipids and other lipid metabolism, etc., being capable f significantly lower the effect of serum cholesterol. It can correct the growth arrest, skin and hair abnormalities, abnormal serum and adipose tissue composition of experimental animals due to lack of essential fatty acids. Lack of it in human beings can affect cell membrane function. Lack in infants can cause eczema. It is currently the major unsaturated fatty acids used to prevent and treat hyperlipidemia. Plant fat is the main source of linoleic acid, of which soybean oil, corn oil and cottonseed oil content is particularly rich. The content in vegetable oil (except palm oil), fish fat and poultry fat is also high. It is generally recommended that the amount of dietary linoleic acid should be equivalent to more than 2% to 3% of the total dietary calories. ;

• Pharmaceutical effects

  Linolenic acid is the unsaturated acids obtained from the extraction and vacuum distillation of the saponification product of soybean oil. It contains over 65% of pure linoleic acid as well as vitamin E being as an antioxidant. Linoleic acid can react with cholesterol to become esters, which is more easily transported, metabolized and excreted, thus reducing blood cholesterol levels. It can also reduce the triglycerides content in the blood. Unsaturated fatty acids may change the distribution of cholesterol in the body, making it deposited in the tissue outside the vessel wall, further reducing the cholesterol content of the vessel wall for preventing and treating atherosclerosis. ;

• Linoleic acid sources and food

  ▼

  ▲

  Fatty acid

  Double Bonds

  Sources

  Linoleic acid

  n-6

  Vegetable oils, margarines, grain

  α- linolenic acid

  n-3

   

    Green leaves, linseed, soybean and canola oil

  EPA, DHA

   

  Marine animals, cod liver oil and fish oil
    Safflower, sunflower, soybean and corn oils are the major sources of omega-6 fatty acids (linoleic acid), which makes up 85 to 90 percent of caloric sources. Pine nuts, pecans and Brazil nuts are also high in linoleic acid. The ideal ratio of omega-3(linolenic acid) and omega-6(linoleic acid) fatty acids is 2:1 to 4:1; however, the standard Western diet provides omega-6(linoleic acid) polyunsaturated fatty acids in excess of 14 times that of omega-3 fatty acids (linolenic acid). ;

• Production

  Linoleic acid is present in the form of glycerides inside the animal body together with other fatty acids. The content in animal fat is generally low; for example, 1.8% iin butter, 6% in lard; some kinds of vegetable oils have high content such as 26% in peanut oil, and 15.8 in rape oil while the soybean fatty acids are mainly linoleic acid. The general composition of soybean fatty acids are as follows: oleic acid 15-33% linoleic acid 53-56% linolenic acid 5-9% palmitic acid 7-11% stearic acid and 2-6% Carbon 20- or more acids. The 0.3-3% soybean oil, will give approximately 5-10% of the oil foot and soap foot during the refining process. Half of the soya bean oil soap is useful fatty acids, while the fatty acids in the soaps are essentially the same as the fatty acid composition of the soya bean oil. Therefore, the use of soybean oil soap for extraction of linoleic acid is an important way to comprehensive utilize the soybean oil. ;

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