Линоленовая кислота

Описание

Linolenic acid (LA), also known as Alpha-linolenic acid (ALA), is an omega-3 essential fatty acid with a wide range of biological activities such as cardiovascular protection, anticancer, neuroprotection, anti-osteoporosis, anti-inflammatory, and antioxidant.LA is mainly sourced from plants, such as nuts and seeds, and is used for the endogenous synthesis of LC omega-6 fatty acids. It is used medicinally as a nutritional supplement and to treat dietary deficiencies or imbalances.

Химические свойства

clear light yellow to yellow liquid

Вхождение

linolenic acid occurs as the glyceride in many seed fats. It is an essential fatty acid in the diet.

Использование

linolenic acid is also known as alpha-linolenic acid; omega-3. An essential fatty acid found in most drying oils. It is slightly irritating to the mucous membranes. It may be used in a cosmetic preparation for any of the following broad uses: anti-static, cleansing, emollient, skin-conditioning, and surfactant properties.

Определение

ChEBI: Alpha-linolenic acid is a linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect. It has a role as a micronutrient, a nutraceutical and a mouse metabolite. It is an omega-3 fatty acid and a linolenic acid. It is a conjugate acid of an alpha-linolenate and a (9Z,12Z,15Z)-octadeca-9,12,15-trienoate.

преимущество

Linolenic acid (LA) is an essential fatty acid with anti-inflammatory, anti-bacterial, anti-atherosclerotic and anti-cancer activities, and has a variety of health benefits, including: lowering high blood pressure and cholesterol, lowering the risk of heart disease, maintaining the membrane fluidity of the epidermal transdermal water barrier, improving the barrier function of the skin, decreasing inflammation, regulating sebum secretion, moisturising the scalp, promoting hair growth and prevents hair breakage. It also has a whitening effect on over-pigmented skin.

Общее описание

Linolenic acid is a clear colorless liquid. (NTP, 1992)

Реакции воздуха и воды

Oxidizes in air to form peroxides, which spontaneously ignite. Insoluble in water. Sensitive to heat and moisture.

Профиль реактивности

Linolenic acid is incompatible with bases, oxidizing agents and reducing agents. Also incompatible with peroxides, oxygen and water.

Пожароопасность

Linolenic acid is probably combustible.

Канцерогенность

Narisawa et al. found that diets high in perilla oil (with high a-linolenic acid but also high levels of linoleic acid) lowered the risk of colon cancer in a rat model initiated with the carcinogen N-methyl-Nnitrosourea. Okuno found a suppressive effect on diethylnitrosamine- induced heptaocarcinogenesis in male Fischer 344 rats treated with either safflower (high in linoleic acid) or perilla oil (high in both linoleic and α-linolenic acids). Kitano et al. found that 10% α-linolenic acid did not promote urninary bladder cancer initiated in rats with N-butyl-N-(4-hydrocybutyl)nitrosamine. Mice fed a-linolenic acid at 5–10% of the diet had increased mammary gland ductular cell proliferation.