АЦЕТИЛ ХЛОРИД

Описание

Acetic chloride is a colourless to light yellow liquid with a pungent and choking odour. Acetic chloride is highly flammable and reacts violently with DMSO, water, lower alcohols, and amines to generate toxic fumes. Along with air, acetic chloride may form an explosive mixture. It is incompatible with water, alcohols, amines, strong bases, strong oxidising agents, and most common metals. On decomposition when heated, acetic chloride produces carbon monoxide, carbon dioxide, hydrogen chloride, and phosgene.

Химические свойства

Acetyl chloride is a highly flammable, colorless, fuming liquid with a pungent odor

Использование

Acetyl chloride acts as a reagent for the preparation of esters and amides of acetic acid. It is also useful an important reactant in Friedel-Crafts reactions as well as the introduction of an acetyl group. It serves as a starting material in the production of pharmaceutical, new plating complexing agent, acylation agent and synthetic organic intermediates.

Определение

A liquid acyl chloride used as an acetylating agent.

Общее описание

A colorless, fuming liquid with a pungent odor. Density 9.2 lb / gal. Flash point 40°F. Vapor, which is heavier than air, irritates the eyes and mucous membranes. Corrosive to metals and tissue.
Acetyl chloride, CH30CCI, can be prepared by treatment ofacetic acid with various reagents, such as PCl3 SOCl2 or COCI2. It can be prepared by chlorination of acetic anhydride in several different ways, by reaction of methyl chloride with carbon monoxide in the presence of catalysts, by reaction ofketene with HCI, or by partial hydrolysis of 1, 1, l-trichloroethane, Acetyl chloride hydrolyzes in the presence of water to give acetic acid. It reacts with ammonia and amines to give acetamides. Reaction with alcohols gives the corresponding acetate esters. Acetyl chloride will add across unsaturated bonds in the presence ofsuitable catalysts to give halogenated ketones.

Профиль реактивности

Acetyl chloride reacts violently with water, steam, methanol or ethanol to form hydrogen chloride and acetic acid. Reacts vigorously with bases, both organic and inorganic. Incompatible with oxidizing agents and alcohols. Produces highly toxic fumes of phosgene gas and chlorine when heated to decomposition [Sax, 9th ed., 1996, p. 35]. Reaction in a confined space with even a small amount of water may cause a violent eruption of gases [Bretherick, 5th ed., 1995, p. 281]. Vapor forms an explosive mixture with air [Kirk-Othmer, 3rd ed., Vol. 1, 1978, p. 162]. Polymerization reaction with dimethyl sulfoxide is particularly violent [Buckley, A., J. Chem. Ed., 1965, 42, p. 674]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Угроза здоровью

Vapor irritates mucous membranes. Ingestion of liquid or contact with eyes or skin causes severe irritation.

Профиль безопасности

Poison by inhalation. Moderately toxic by ingestion. A human systemic irritant by inhalation. Violent hydrolysis reaction with water or steam produces heat, acetic acid, HCl, and other corrosive chlorides. May decompose during preparation. Dangerous fire hazard when exposed to heat or flame. Explosion hazard by spontaneous chemical reaction with dimethyl sulfoxide or ethanol. Also incompatible with Pcb. When heated to decomposition it emits highly toxic fumes of phosgene and Cl-. To fight fire, use CO2 or dry chemical. See also CHLORIDES

Возможный контакт

Acetyl chloride is used in organic synthesis as an acetylating agent and in testing for water and/ or cholesterol in organic liquids, in the pharmaceutical industry and in pesticide manufacture.

Химические свойства

Ацетилхлорид — хлорангидрид уксусной кислоты, летучая бесцветная жидкость с резким раздражающим запахом, дымящая на воздухе.

Применение

Сильный электрофил, широко используется в органическом синтезе в качестве ацилирующего агента для введения в синтезируемую молекулу ацетильной группы (ацетила) CH3CO при этерификации.

синтез

В промышленности ацетилхлорид синтезируют реакцией уксусной кислоты с хлоридами фосфора (треххлористым или пятихлористым фосфором):

недостаток этого метода — необходимость ректификации продуктов из-за близости точек кипения продукта и хлористого тионила.

Безопасность

Бесцветная или светло-желтая жидкость с резким запахом.Легковоспламеняемо. Бурно реагирует с ДМСО, водой, низшими спиртами и аминами, генерируя токсичные газы. Может образовывать взрывоопасную смесь с воздухом.

хранилище

Acetic chloride should be stored in a segregated and approved area, away from incompatibles such as oxidizing agents, alkalis and moisture. The container of acetic chloride should be kept in a cool, well-ventilated area, tightly sealed until ready for use. Users should avoid all possible sources of ignition, i.e., spark or flames.

Перевозки

UN1717 Acetyl chloride, Hazard Class: 3; Labels: 3-Flammable liquid, 8-Corrosive material

Методы очистки

Reflux acetyl chloride with PCl5 for several hours to remove traces of acetic acid, then distil it. Redistil it from one-tenth its volume of dimethylaniline or quinoline to remove free HCl. A.R. quality is freed from HCl by pumping it for 1hour at -78o and distilling it into a trap at -196o. [Beilstein 2 IV 395.] LACHRYMATORY.

Несовместимости

ticide manufacture. Incompatibilities: Avoid contact with moisture, steam, water, alcohols, dimethylsulfoxide, strong bases; phosphorus trichloride; oxidizers, and amines, since violent reactions may occur. Keep away from heat, fire, and welding operations.

Утилизация отходов

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. May be mixed slowly with sodium bicarbonate solution and then flushed to sewer with large volumes of water. May also be incinerated.