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АНГИДРИД УКСУСНОЙ КИСЛОТЫ
- английское имяAcetic anhydride
- CAS №108-24-7
- CBNumberCB2852742
- ФормулаC4 H6 O3
- мольный вес102.09
- EINECS203-564-8
- номер MDLMFCD00008705
- файл Mol108-24-7.mol
Температура плавления | -73.1 °C |
Температура кипения | 140 °C |
плотность | 1.087 |
плотность пара | 3.5 (vs air) |
давление пара | 10 mm Hg ( 36 °C) |
показатель преломления | n |
Fp | 130 °F |
температура хранения | Store at RT. |
растворимость | Miscible with ether, chloroform and benzene. |
форма | Liquid |
цвет | Colorless |
Удельный вес | 1.082 |
РН | 3 (10g/l, H2O, 20°C) |
Запах | Very strong; pungent; vinegar-like characteristic odor. |
Пределы взрываемости | 2.0-10.2%(V) |
Odor Type | acidic |
Растворимость в воде | REACTS |
Чувствительный | Moisture Sensitive |
Мерк | 14,56 |
БРН | 385737 |
Диэлектрическая постоянная | 20.0 |
Пределы воздействия | NIOSH REL: ceiling 5 ppm (20 mg/m3), IDLH 200 ppm; OSHA PEL: 5 ppm; ACGIH TLV: ceiling 5 ppm. |
Стабильность | Stability Flammable. Incompatible with strong oxidizing agents, water, strong bases, alcohols. |
LogP | -0.58 at 20℃ |
Вещества, добавляемые в пищу (ранее EAFUS) | ACETIC ANHYDRIDE |
Справочник по базе данных CAS | 108-24-7(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 3 |
FDA UNII | 2E48G1QI9Q |
Справочник по химии NIST | Acetic acid anhydride(108-24-7) |
Система регистрации веществ EPA | Acetic anhydride (108-24-7) |
Коды опасности | C,Xn,F,Xi | |||||||||
Заявления о рисках | 11-20/21/22-37/38-41-34-20/21-10-20/22-19-40 | |||||||||
Заявления о безопасности | 26-39-45-36/37/39-33-16 | |||||||||
РИДАДР | UN 2924 3/PG 2 | |||||||||
OEL | Ceiling: 5 ppm (20 mg/m3) | |||||||||
WGK Германия | 3 | |||||||||
RTECS | AK1925000 | |||||||||
F | 21 | |||||||||
Температура самовоспламенения | 629 °F | |||||||||
TSCA | Yes | |||||||||
Класс опасности | 8 | |||||||||
Группа упаковки | II | |||||||||
кода HS | 29152400 | |||||||||
Банк данных об опасных веществах | 108-24-7(Hazardous Substances Data) | |||||||||
Токсичность | LD50 orally in rats: 1.78 g/kg (Smyth) | |||||||||
ИДЛА | 200 ppm | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H302:Вредно при проглатывании.
H314:При попадании на кожу и в глаза вызывает химические ожоги.
H226:Воспламеняющаяся жидкость. Пары образуют с воздухом взрывоопасные смеси.
H330:Смертельно при вдыхании.
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оператор предупредительных мер
P210:Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P280:Использовать перчатки/ средства защиты глаз/ лица.
P301+P312:ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P303+P361+P353:ПРИ ПОПАДАНИИ НА КОЖУ (или волосы): Снять/удалить немедленно всю загрязненную одежду. Промыть кожу водой.
P304+P340+P310:ПРИ ВДЫХАНИИ: Свежий воздух, покой. Немедленно обратиться за медицинской помощью.
P305+P351+P338:ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
АНГИДРИД УКСУСНОЙ КИСЛОТЫ химические свойства, назначение, производство
Описание
Acetic anhydride (chemical formula: (CH3CO)2O) is the simplest isolable anhydride of a carboxylic acid, is widely used as a reagent in organic synthesis. It has an internal asymmetric structure, leading to its potent electrophilicity. In organic chemistry, it is mainly used in acetylation for the manufacture of commercially significant materials, e.g. it can be used for the conversion of cellulose to cellulose acetate and aspirin. It can also be used as a wood preservative. In starch industry, it is a common acetylation compound for acetylation of monoglyceride. It is also an esterification agent for the production of modified starches. It is produced by carbonylation of methyl acetate or the reaction between ketene and acetic acid.Химические свойства
Acetic anhydride, or ethanoic anhydride, is the chemical compound with the formula (CH3CO)2O. Commonly abbreviated Ac2O, it is the simplest isolatable acid anhydride and is a widely used reagent in organic synthesis. It is a combustible, colorless, strongly refractive, liquid that smells strongly of acetic acid, formed by its reaction with the moisture in the air. Acetic anhydride is an esterification agent used in the preparation of modified starch and for acetylation of acetylated monoglycerides.Физические свойства
Acetic anhydride is a colorless, very mobile liquid with a very strong, acetic acid-like odor. Experimentally determined detection and recognition odor threshold concentrations were <600 μg/m3 (<140 ppbv) and 1.5 mg/m3 (360 ppbv), respectively (Hellman and Small, 1974). Acetic anhydride is miscible with polar solvents and dissolves in cold alcohol with slow decomposition. The solubility of acetic anhydride in water at 20°C is 2.6wt%, with slow decomposition; the solubility of water in acetic anhydride at 15°C is 10.7 wt%, with gradual decomposition.Вхождение
Reported found in watercress (Nasturtium officinale r. br.).Использование
Acetic anhydride is an important solvent and acetylation agent. It is used for the manufacture of acetylcellulose, acetylsalicylic acid, acetanilide, nitrofurane, sulfonamides, vitamin B6 etc. As acetulizer and solvent in examining wool fat, glycerol, fatty and volatile oils, resins; detection of rosin. Widely used in organic syntheses, e.g., as dehydrating agent in nitrations, sulfonations and other reactions where removal of water is necessary.Определение
ChEBI: Acetic anhydride is an acyclic carboxylic anhydride derived from acetic acid. It has a role as a metabolite and a reagent.прикладной
As indicated by its organic chemistry, Ac2O is mainly used for acetylations leading to commercially significant materials. Its largest application is for the conversion of cellulose to cellulose acetate, which is a component of photographic film and other coated materials. Similarly it is used in the production of aspirin (acetylsalicylic acid), which is prepared by the acetylation of salicylic acid.It is also used as a wood preservative via autoclave impregnation to make a longer lasting timber.In starch industry, acetic anydride is a common acetylation compound, used for the production of modified starches
Because of its use for the synthesis of heroin by the diacetylation of morphine, acetic anhydride is listed as a U.S. DEA List II precursor, and restricted in many other countries.
Реакции
introduction of acetyl groups to organic substrates . In these conversions, acetic anhydride is viewed as a source of CH3CO+. Alcohols and amines are readily acetylated. For example, the reaction of acetic anhydride with ethanol yields ethyl acetate:(CH3CO)2O + CH3CH2OH → CH3CO2CH2CH3 + CH3COOH
Often a base such as pyridine is added to function as catalyst. In specialized applications, Lewis acidic scandium salts have also proven effective catalysts.
Aromatic rings are acetylated, usually in the presence of an acid catalyst. Illustrative is the conversion of benzene to aceto phenone:
(CH3CO)2O + C6H6 → CH3COC6H5 + CH3CO2H
Ferrocene can be acetylated as well:
Cp2Fe + (CH3CO)2O → CpFe(C5H4COCH3).
Общее описание
A clear colorless liquid with a strong odor of vinegar. Flash point 129°F. Corrosive to metals and tissue. Density 9.0 lb /gal. Manufacture of cellulose esters, plastics, pharmaceuticals, photographic films, cigarette filters, and magnetic tape; inorganic synthesis as an acetylating agent, bleaching agent, and dehydrating agent.Реакции воздуха и воды
Flammable. Reacts violently with water to generate acetic acid . This reaction is heightened by the presence of mineral acids (nitric, perchloric, sulfuric acid, etc.) [Chem. Eng. News 25, 3458].Профиль реактивности
Acetic anhydride reacts violently on contact with water, steam, methanol, ethanol, glycerol and boric acid. Reaction with water is particularly dangerous in presence with mineral acids (e.g., nitric, perchloric, chromic, sulfuric acid) [Chem. Eng. News 25, 3458]. Potentially explosive reactions with oxidizing reagents such as barium peroxide, chromium trioxide, chromic acid, hypochlorous acid, nitric acid, perchloric acid, peroxyacetic acid, potassium permanganate, hydrogen peroxide. [Sax, 9th ed., 1996, p. 15]. Reacts violently with metal nitrates used as nitrating agents [Davey W. et al., Chem. & Ind., 1948, p. 814].Угроза здоровью
Liquid is volatile and causes little irritation on uncovered skin. However, causes severe burns when clothing is wet with the chemical or if it enters gloves or shoes. Causes skin and eye burns and irritation of respiratory tract. Nausea and vomiting may develop after exposure.Химическая реактивность
Reactivity with Water: Reacts slowly with water, but considerable heat is liberated when contacted with spray water; Reactivity with Common Materials: Corrodes iron, steel and other metals; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Dilute with water and use sodium bicarbonate solution to rinse; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.Профиль безопасности
Moderately toxic by inhalation, ingestion, and skin contact. A skin and severe eye irritant. A flammable liquid. A fire and explosion hazard when exposed to heat or flame. Potentially explosive reactions with barium peroxide, boric acid, chromium trioxide, 1,3diphenyltriazene, hydrochloric acid + water, hypochlorous acid, nitric acid, perchloric acid + water, peroxyacetic acid, potassium permanganate, tetrafluoroboric acid, 4toluenesulfonic acid + water, and acetic acid + water. Reactions with ethanol + sodium hydrogen sulfate, and hydrogen peroxide form explosive products. Reactions with ammonium nitrate + hexamethylenetetrammonium acetate + nitric acid form as products the military explosives RDX and HMX. Reacts violently with N-tert-butyl-phthalimic acid + tetrafluoroboric acid, chromic acid, glycerol + phosphoryl chloride, and metal nitrates (e.g., copper or sodium nitrates). Incompatible with 2-aminoethanol, aniline, chlorosulfonic acid, (CrOs + acetic acid), ethylene-diamine, ethyleneimine, glycerol, oleum, HF, permanganates, NaOH, Na2O2, H2SO4, water, N2O2, (glycerol + phosphoryl chloride). When heated to decomposition it emits toxic fumes; can react vigorously with oxidizing materials, wdl react violently on contact with water or steam. Used in production of drugs of abuse. To fight fire, use CO2, dry chemical, water mist, alcohol foam. See also ANHYDRIDES.Возможный контакт
Acetic anhydride is used as an acetylating agent or as a solvent in the manufacture of cellulose acetate, acetanilide, aspirin, synthetic fibers, plastics, explosives, resins, perfumes, and flavorings; and it is used in the textile dyeing industry. It is widely used as a pharmaceutical intermediate and as a pesticide intermediateЭкологическая судьба
Chemical/Physical. Slowly dissolves in water forming acetic acid. In ethanol, ethyl acetate is formed (Windholz et al., 1983).Перевозки
UN1715 Acetic anhydride, Hazard class: 8; Labels: 8-Corrosive material, 3-Flammable liquid.Методы очистки
Adequate purification can usually be achieved by fractional distillation through an efficient column. Acetic acid can be removed by prior refluxing with CaC2 or with coarse Mg filings at 80-90o for 5days, or by distillation from a large excess of quinoline (1% AcOH in quinoline) at 75mm pressure. Acetic anhydride can also be dried by standing with Na wire for up to a week, removing the Na and distilling it under vacuum. (Na reacts vigorously with acetic anhydride at 65-70o). Dippy & Evans [J Org Chem 15 451 1950] let the anhydride (500g) stand over P2O5 (50g) for 3hours, then decanted it and stood it with ignited K2CO3 for a further 3hours. The supernatant liquid was distilled and the fraction b 136-138o was further dried with P2O5 for 12hours, followed by shaking with ignited K2CO3, before two further distillations through a five-section Young and Thomas fractionating column. The final material distilled at 137.8-138.0o. It can also be purified by azeotropic distillation with toluene: the azeotrope boils at 100.6o. After removal of the remaining toluene, the anhydride is distilled [sample had a specific conductivity of 5 x 10-9 ohm-1cm -1]. [Beilstein 2 H 96, 2 I 39, 2 II 91, 2 III 134, 2 IV 94.] Rapid procedure: Shake with P2O5, separate, shake with dry K2CO3 and fractionally distil.Несовместимости
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols, chromic acid (violent reaction), amines, strong caustics; finely divided metals. Contact with water forms acetic acid and liberates a large amount of heat. Corrosive to iron, steel and other metals.Утилизация отходов
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.АНГИДРИД УКСУСНОЙ КИСЛОТЫ запасные части и сырье
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