Пенгитоксин
- английское имяPengitoxin
- CAS №7242-04-8
- CBNumberCB11118358
- ФормулаC51H74O19
- мольный вес991.12
- EINECS230-645-5
- файл Mol7242-04-8.mol
химическое свойство
| Температура плавления | 151-155° |
| альфа | D20 +14.0 ±1.5° (c = 1.6 in pyridine) |
| Температура кипения | 742.94°C (rough estimate) |
| плотность | 1.1187 (rough estimate) |
| показатель преломления | 1.6500 (estimate) |
| Растворимость в воде | 11.89mg/L(temperature not stated) |
| FDA UNII | 15RPL803R9 |
| Токсичность | LD50 in mice (mg/kg): 6.4 i.p.; in rats (mg/kg): 21.0 i.v. (Foerster) |
Пенгитоксин химические свойства, назначение, производство
Создатель
Pengitoxin,Shanghai LanshengПроизводственный процесс
Gitoxin is isolated from leaves of Digitalis purpurea L. genus Scrofphulariaceae.10.0 g pure gitoxin are boiled under reflux with 1 L pure acetic anhydride. Gitoxin thereby goes into solution in the course of 1 h. The boiling is discontinued after 1 h and the acetic anhydride distilled off in a vacuum as completely as possible. After taking up the oily residue with 500 ml chloroform, the solution is successively washed with 200 ml of 2 N potassium bicarbonate solution, 0.1 N hydrochloric acid and water. After drying the chloroform solution with anhydrous sodium sulfate, the chloroform is first distilled off over an open flame and then on a water bath at 40°C in a vacuum, a substantially crystalline residue thereby being obtained. The 12.8 g of crude product obtained are recrystallized from 12 times the amount of a mixture of pyridine, methanol and water (25:10:65) to give rhombic crystals, melting point 151°-155°C.
Терапевтическая функция
Cardiotonic