Basic information Safety Related Supplier
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Inhibitors >  Neuronal Signaling >  AChR antagonist >  Darifenacin hydrobromide

Darifenacin hydrobromide

Basic information Safety Related Supplier
Darifenacin hydrobromide Basic information
Darifenacin hydrobromide Chemical Properties
  • Melting point:228-2300C
  • alpha 25D -30.3° (c = 1.0 in methylene chloride)
  • storage temp. -20°C Freezer
  • solubility DMSO: soluble20mg/mL, clear
  • form powder
  • color white to beige
  • optical activity[α]/D +41 to +49°, c = 1 in methylene chloride
  • CAS DataBase Reference133099-07-7(CAS DataBase Reference)
Safety Information
  • WGK Germany 3
  • HS Code 2934990002
Darifenacin hydrobromide Usage And Synthesis
  • Chemical PropertiesWhite Solid
  • UsesDarifenacin hydrobromide is used as a medication to treat urinary incontinence. It works by blocking the M3 muscarinic acetylcholine receptor.
  • Usescalcium replenisher
  • Usesacute lymphoblastic leukemia therapeutic
  • DefinitionChEBI: The hydrobromide salt of darifenacin. A selective antagonist for the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions, it is used in the management of urinary incontinence.
  • brand nameEnablex (Novartis).
  • General DescriptionDarfenacin (Enablex),(s)-2-{1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphen-ylacetamide, is an antimuscarinicagent that has selectivity for the M3 muscarinicsubtype receptor. By competitively blocking of the muscarinicreceptors results in a reduction of the smoothmuscle tone, allowing for greater volume of urine to bestored in the bladder. This results in less urinary incontinence,urgency, and frequency. It is a white to almostwhite, crystalline powder, with a molecular weight of507.5. Darifenacin is metabolized by the isozymesCYP2D6 and CYP3A4 with the primary metabolic routesbeing monohydroxylation of the dihydrobenzofuran ring,opening of the dihydrobenzofuran ring, and N-dealkylationof the pyrrolidine nitrogen.
Darifenacin hydrobromide(133099-07-7)Related Product Information
Darifenacin hydrobromideSupplierMore
  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Email:jkinfo@jkchemical.com;market6@jkchemical.com
  •  
  • Company Name:Chembest Research Laboratories Limited
  • Tel:021-20908456-
  • Email:sales@BioChemBest.com
  •  
  • Company Name:BeiJing Hwrk Chemicals Limted
  • Tel:18600197062 0757-86311057-
  • Email:kennyrong@hwrkchemical.com
  •  
  • Company Name:Capot Chemical Co., Ltd
  • Tel:+86 (0) 571 85 58 67 18
  • Email:sales@capotchem.com
  •  
  • Company Name:JinYan Chemicals(ShangHai) Co.,Ltd.
  • Tel:13817811078,021-50426030
  • Email:sales@jingyan-chemical.com
  •