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Scopolamine hydrobromide

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Scopolamine hydrobromide Basic information
Scopolamine hydrobromide Chemical Properties
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22
  • Safety Statements 36
  • RIDADR UN 1544 6.1/PG 1
  • WGK Germany 3
  • RTECS YM4550000
  • 3-8
  • HS Code 2939800000
  • ToxicityLD50 in rats (mg/kg): 3800 s.c. (Stockhaus, Wick)
MSDS
Scopolamine hydrobromide Usage And Synthesis
  • Chemical PropertiesOff-White Solid
  • UsesAn acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant
  • DefinitionChEBI: A hydrobromide that is obtained by reaction of scopolamine with hydrogen bromide.
  • brand nameIsopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).
  • General DescriptionScopolamine hydrobromide(hyoscine hydrobromide) occurs as white orcolorless crystals or as a white, granular powder. It is odorlessand tends to effloresce in dry air. It is freely soluble inwater (1:1.5), soluble in alcohol (1:20), only slightly solublein chloroform, and insoluble in ether.
    Scopolamine is a competitive blocking agent of theparasympathetic nervous system as is atropine, but it differsmarkedly from atropine in its action on the higher nervecenters. Both drugs readily cross the blood-brain barrierand, even at therapeutic doses, cause confusion, particularlyin the elderly.
  • General DescriptionColorless crystals or white powder or solid. Has no odor. pH (of 5% solution): 4-5.5. Slightly efflorescent in dry air. Bitter, acrid taste.
  • Air & Water ReactionsSensitive to air, light and moisture. Water soluble.
  • Reactivity ProfileScopolamine hydrobromide is incompatible with acids, bases and oxidizing agents. .
  • Fire HazardFlash point data for Scopolamine hydrobromide are not available; however, Scopolamine hydrobromide is probably combustible.
  • Biological ActivityNon-selective muscarinic antagonist. Widely used clinically to treat motion sickness.
  • Clinical UseA sufficiently large dose of scopolamine will cause an individualto sink into a restful, dreamless sleep for about8 hours, followed by a period of approximately the samelength in which the patient is in a semiconscious state.During this time, the patient does not remember events thattake place. When scopolamine is administered with morphine,this temporary amnesia is termed twilight sleep.
  • Purification MethodsThe hydrobromide is recrystallised from Me2CO, H2O or EtOH/Et2O and dried. It is soluble in H2O (60%) and EtOH (5%) but insoluble in Et2O and slightly in CHCl3. The hydrochloride has m 300o (from Me2CO). The free base is a viscous liquid which forms a crystalline hydrate with m 59o and [] D 20 -28o (c 2.7, H2O). It hydrolyses in dilute acid or base. [Meinwald J Chem Soc 712 1953, Fodor Tetrahedron 1 86 1957, Beilstein 6 III 4185.]
Scopolamine hydrobromide Preparation Products And Raw materials
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