White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.
Antiemetic;Non-selective muscarinic antagonist
Competitive nonselective muscarinic acetylcholine antagonist. Scopolamine-induced amnesia in laboratory animals is a commonly-used model of memory deficit.
Scopolamine induces memory impairment associated with attenuation of cholinergic neurotransmission, as well as an increases of processes connected with oxidative stress in the brain[3].
| Animal Model: | Naive male Swiss mice weighing 20-25[3] |
| Dosage: | 1 mg/kg |
| Administration: | Administered intraperitoneally (i.p.); to measure the memory acquisition processes, Scopolamine was administered 20 min before the pretest; to measure the memory consolidation processes, Scopolamine was administered immediately after the pretest |
| Result: | In scopolamine-treated group, there was a significant decrease in the index of latency (IL) value as compared with the saline-treated mice, indicating that scopolamine at the used dose impaired acquisition of memory and learning. |
5-HT3 Receptor: 2.09 μM (IC50)
