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Scopolamine hydrobromide

Scopolamine hydrobromide Structure
Scopolamine hydrobromide
  • CAS No.114-49-8
  • Chemical Name:Scopolamine hydrobromide
  • CBNumber:CB9363236
  • Molecular Formula:C17H21NO4.BrH
  • Formula Weight:384.26
  • MOL File:114-49-8.mol
Scopolamine hydrobromide Property
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • Safety Statements  :36
  • RIDADR  :UN 1544 6.1/PG 1
  • WGK Germany  :3
  • RTECS  :YM4550000
  • F  :3-8
  • HS Code  :2939800000
  • Toxicity :LD50 in rats (mg/kg): 3800 s.c. (Stockhaus, Wick)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Scopolamine hydrobromide Price More Price(29)
  • Brand: Sigma-Aldrich
  • Product number: PHR1470
  • Product name : Scopolamine Hydrobromide
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging: 500 mg
  • Price: $92.7
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: S0929
  • Product name : Scopolamine hydrobromide
  • Purity: meets USP testing specifications
  • Packaging: 1 g
  • Price: $60.4
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: S0929
  • Product name : Scopolamine hydrobromide
  • Purity: meets USP testing specifications
  • Packaging: 5 g
  • Price: $230
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1610001
  • Product name : Scopolamine hydrobromide
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 500 mg
  • Price: $366
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: S0929
  • Product name : Scopolamine hydrobromide
  • Purity: meets USP testing specifications
  • Packaging: 25 g
  • Price: $951
  • Updated: 2021/12/16
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Scopolamine hydrobromide Chemical Properties,Usage,Production

  • Description Scopolamine is a tropane alkaloid that can be found in many plants of the Solanaceae (nightshade) family. It is a muscarinic receptor antagonist that can be used to induce memory impairment in animals. Scopolamine prevents motion sickness, nausea, and vomiting in animals.
  • Chemical Properties Off-White Solid
  • Uses An acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant
  • Definition ChEBI: A hydrobromide that is obtained by reaction of scopolamine with hydrogen bromide.
  • brand name Isopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).
  • General Description Scopolamine hydrobromide(hyoscine hydrobromide) occurs as white orcolorless crystals or as a white, granular powder. It is odorlessand tends to effloresce in dry air. It is freely soluble inwater (1:1.5), soluble in alcohol (1:20), only slightly solublein chloroform, and insoluble in ether.
    Scopolamine is a competitive blocking agent of theparasympathetic nervous system as is atropine, but it differsmarkedly from atropine in its action on the higher nervecenters. Both drugs readily cross the blood-brain barrierand, even at therapeutic doses, cause confusion, particularlyin the elderly.
  • General Description Colorless crystals or white powder or solid. Has no odor. pH (of 5% solution): 4-5.5. Slightly efflorescent in dry air. Bitter, acrid taste.
  • Air & Water Reactions Sensitive to air, light and moisture. Water soluble.
  • Reactivity Profile Scopolamine hydrobromide is incompatible with acids, bases and oxidizing agents. .
  • Fire Hazard Flash point data for Scopolamine hydrobromide are not available; however, Scopolamine hydrobromide is probably combustible.
  • Biological Activity Non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.
  • Clinical Use A sufficiently large dose of scopolamine will cause an individualto sink into a restful, dreamless sleep for about8 hours, followed by a period of approximately the samelength in which the patient is in a semiconscious state.During this time, the patient does not remember events thattake place. When scopolamine is administered with morphine,this temporary amnesia is termed twilight sleep.
  • Purification Methods The hydrobromide is recrystallised from Me2CO, H2O or EtOH/Et2O and dried. It is soluble in H2O (60%) and EtOH (5%) but insoluble in Et2O and slightly in CHCl3. The hydrochloride has m 300o (from Me2CO). The free base is a viscous liquid which forms a crystalline hydrate with m 59o and [] D 20 -28o (c 2.7, H2O). It hydrolyses in dilute acid or base. [Meinwald J Chem Soc 712 1953, Fodor Tetrahedron 1 86 1957, Beilstein 6 III 4185.]
Scopolamine hydrobromide Preparation Products And Raw materials
Raw materials
Preparation Products
Global(409)Suppliers
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