3-Amino-2(1H)-pyridinone

6332-56-5

33630-99-8

a) Synthesis of 3-aminopyridin-2-ol: In a 500 mL three-necked flask, 3-nitropyridin-2(1H)-one (1 g, 7.14 mmol) was dissolved in methanol (200 mL), followed by addition of 10% palladium/activated carbon catalyst (100 mg, 10 wt%). The reaction mixture was stirred for 3 h under hydrogen atmosphere (1 atm) and at room temperature (25°C). Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad, and the filtrate was concentrated under reduced pressure by rotary evaporator to afford the white solid product 3-aminopyridin-2-ol (800 mg, quantitative yield). Product characterization data: 1H-NMR (CD3OD, 300 MHz) δ 6.78-6.73 (m, 2H), 6.23 (t, J = 6.5 Hz, 1H); MS (ESI) m/z 111.1 [M+H]+.