2-Hydroxypyridine CAS#: 142-08-5

2-Hydroxypyridine

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2-Hydroxypyridine Basic information

2-Hydroxypyridine Chemical Properties

Melting point:105-107 °C(lit.)
Boiling point:280-281 °C(lit.)
Density 1.39
refractive index 1.5939 (estimate)
Flash point:210 °C
storage temp. Store at RT.
solubility 450g/l
pka0.75(at 20℃)
form Liquid
color Colorless to yellow to brown, darken on storage with no loss of purity
Water Solubility Soluble in water 450 g/L @ 20°C and ethanol, slightly soluble in benzene and ether.
BRN 105786
CAS DataBase Reference142-08-5(CAS DataBase Reference)
NIST Chemistry Reference2(1H)-Pyridinone(142-08-5)
EPA Substance Registry System2(1H)-Pyridinone (142-08-5)

Safety Information

MSDS

2-Hydroxypyridine Usage And Synthesis

Chemical Propertieswhite to light yellow crystal
UsesCatalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols1 and in the aminolysis of a polyglutamate.2
DefinitionChEBI: A monohydroxypyridine that is pyridine substituted by a hydroxy group at position 2.
Safety ProfileModerately toxic by intraperitoneal and intravenous routes. A combustible liquid. When heated to decomposition it emits toxic vapors of NOx.
Purification MethodsDistil the pyridone under vacuum to remove coloured impurity, then recrystallise from *benzene, CCl4, EtOH or CHCl3/diethyl ether. It can be sublimed under high vacuum. [DePue et al. J Am Chem Soc 107 2131 1985, Beilstein 21/7 V 106.]

2-Hydroxypyridine Preparation Products And Raw materials

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