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4-Chlorophenol Basic information
4-Chlorophenol Chemical Properties
  • Melting point:42-45 °C
  • Boiling point:220 °C (lit.)
  • Density 1.306 g/mL at 25 °C (lit.)
  • vapor density 4.43 (vs air)
  • vapor pressure 1 mm Hg ( 49.8 °C)
  • refractive index 1.5579
  • Flash point:240 °F
  • storage temp.  0-6°C
  • solubility ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow
  • form Low Melting Crystalline Mass
  • pka9.18(at 25℃)
  • color White to pale yellow
  • OdorPhenolic like 30 ppm
  • Odor Threshold30 ppm
  • Water Solubility 2.7 g/100 mL (20 ºC)
  • Sensitive Air Sensitive
  • Merck 14,2154
  • BRN 507004
  • Stability:Stable. Incompatible with acid chlorides, acid anhydrides, oxidizing agents, iron.
  • CAS DataBase Reference106-48-9(CAS DataBase Reference)
  • NIST Chemistry Referencep-Chlorophenol(106-48-9)
  • EPA Substance Registry Systemp-Chlorophenol (106-48-9)
Safety Information
4-Chlorophenol Usage And Synthesis
  • Chemical Propertiesoff-white to light tan crystals or powder
  • Chemical PropertiesAll isomers have a characteristic odor.
  • UsesIntermediates of Liquid Crystals
  • Usesantineoplastic
  • UsesBiocide; disinfectant for home, hospital and farm.
  • DefinitionChEBI: A monochlorophenol substituted at the pare position by a chlorine atom.
  • Synthesis Reference(s)The Journal of Organic Chemistry, 50, p. 2145, 1985 DOI: 10.1021/jo00212a029
    Tetrahedron Letters, 24, p. 3117, 1983 DOI: 10.1016/S0040-4039(00)88111-3
  • General DescriptionWhite crystals with a strong phenol odor Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible. Used as an intermediate in organic synthesis of dyes and drugs.
  • Air & Water ReactionsSlightly soluble to soluble in water.
  • Reactivity ProfileCHLOROPHENOLS, SOLID are incompatible with acid chlorides, acid anhydrides and oxidizing agents. Also incompatible with iron . Liquefy and darken in color at temperatures above 108°F.
  • HazardToxic by skin absorption, inhalation, or ingestion; strong irritant to tissue.
  • Health HazardInhalation causes headache, dizziness, weak pulse. Ingestion causes irritation of mouth and stomach; headache, dizziness, weak pulse. Contact with eyes causes severe irritation and burning. Contact with skin causes irritation and burn; if absorbed, causes same symptoms as inhalation.
  • Fire HazardSpecial Hazards of Combustion Products: Toxic and irritating hydrogen chloride and chlorine gases may form in fires.
  • Safety ProfilePoison by inhalation and intraperitoneal routes. Moderately toxic by ingestion, skin contact, and subcutaneous routes. A severe skin and eye irritant. Human systemic effects by inhalation: excitement, irritability. Mutation data reported. Combustible when exposed to heat or flame. To fight fire, use water, spray, mist, fog, foam, dry chemical. When heated to decomposition it emits toxic fumes of Cl-. See also CHLOROPHENOLS and CHLORIDES.
  • Potential ExposureMonochlorophenols are used in the manufacture of fungicides, slimicides, bactericides, pesticides, herbicides, disinfectants, wood and glue preservatives; in the production of phenolic resins; in the extraction of certain minerals from coal; as a denaturant for ethanol; as an antiseptic; as a disinfectant, and others.
  • ShippingUN 2020 (solid); UN2021 (liquid) Chlorophenols, solid and liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
  • Purification MethodsDistil the phenol, then crystallise it from pet ether (b 40-60o) or hexane, and dry it under vacuum over P2O5 at room temperature. [Bernasconi & Paschalis J Am Chem Soc 108 2969 1986, Beilstein 6 IV 820.]
  • IncompatibilitiesMay form explosive mixture with air. Contact with oxidizing agents can cause fire and explosion hazard. Heat produces hydrogen chloride and chlorine. Corrosive to aluminum, copper and other chemically active metals.
  • Waste DisposalIncinerate in admixture with flammable solvent in furnace equipped with afterburner and scrubber.
4-Chlorophenol Preparation Products And Raw materials
4-Chlorophenol(106-48-9)Related Product Information
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