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Benzyl nicotinate

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Benzyl nicotinate Basic information
Benzyl nicotinate Chemical Properties
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/38
  • Safety Statements 26
  • WGK Germany 2
  • RTECS QT0850000
  • 8
  • TSCA Yes
MSDS
Benzyl nicotinate Usage And Synthesis
  • Chemical PropertiesBenzyl nicotinate is a benzyl ester resulting from the formal condensation of the carboxy group of nicotinic acid with benzyl alcohol. It derives from a nicotinic acid. It is a vasodilator agent and is also generally used in cosmetics and drugs.It has been used as a rubefacient.
    Benzyl nicotinate can be used for the synthesis of benzylpalladium complexes to be used as catalysts for the substitution of olefins with benzylic groups.
  • Usesbenzyl nicotinate can increase skin oxygenation—thanks to vasodilatation properties—and help stimulate the healing process of wounded skin. It is an ester form of niacin (vitamin B), benzyl alcohol, and nicotinic acid.
  • DefinitionChEBI: A benzyl ester resulting from the formal condensation of the carboxy group of nicotinic acid with benzyl alcohol. It has been used as a rubefacient.
  • Synthesis Reference(s)Synthetic Communications, 14, p. 515, 1984 DOI: 10.1080/00397918408059573
  • Clinical UseBenzyl nicotinate is used in combination with heparin in the treatment of inflammation of vein (thrombophlebitis), pain in dilated veins area, pains and cramps in the leg muscles, disturbances of lymph circulation, traffic and sports related injuries, postoperative and posttraumatic scars, non-joint rheumatism or soft tissue rheumatism.
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