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Inositol nicotinate

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Inositol nicotinate Basic information
Inositol nicotinate Chemical Properties
  • Melting point:254-256 °C(lit.)
  • Boiling point:755.54°C (rough estimate)
  • Density 1.3348 (rough estimate)
  • refractive index 1.6400 (estimate)
  • storage temp. Inert atmosphere,Room Temperature
  • pka3.92±0.10(Predicted)
  • Merck 13,5002
  • CAS DataBase Reference6556-11-2(CAS DataBase Reference)
  • EPA Substance Registry SystemInositol nicotinate (6556-11-2)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-36
  • WGK Germany 2
  • RTECS NM7535400
Inositol nicotinate Usage And Synthesis
  • OriginatorHexanicotol,Philadelphia,US,1962
  • Usesmyo-Inositol Hexanicotinate is an nicotinate conjugate of myo-inositol, an structural basis for a number of secondary messengers.
  • Usesbenzidine substitute
  • Manufacturing Process100 g of nicotinic acid were suspended in 265 ml of distilled and dried pyridine without stirring. 68 g of phosphorus oxychloride were added dropwise to this mixture under continual stirring. The temperature of the reactants, initially at 20°C, was allowed to rise to about 60°C, and this temperature was maintained for a further 60 minutes. Thereafter 24.5 g of meso-inositol wereadded gradually, the temperature being controlled so that it did not exceed about 80°C. The reactants were maintained at this temperature for from 2 to 3 hours, and thereafter the reaction mixture was poured into 500 ml of water. The pyridine salts formed during the reaction readily dissolved, and the mesoinositol hexanicotinate which had formed crystallized out. The ester was filtered off and washed with water and acetone or alcohol. Finally, the mesoinositol hexanicotinate was dried at 100°C.
    The yield was 90%, the melting point of the product was 258°C to 260°C. and the chlorine content <0.01%.
  • brand nameHexopal (Sterling Winthrop); Linodil (Sterling Winthrop); Palohex (Sterling Winthrop).
  • Therapeutic FunctionVasodilator
Inositol nicotinate (6556-11-2)Related Product Information
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