Hyperan,S.S. Pharm,Japan,1980
Exalamide is used as an antifungal (topical). Exalamide is a derivative of salicylamide.
ChEBI: An arenecarboxamide that is salicylamide in which the phenolic hydroxy group has been converted to the corresponding hexyl ether. It has been used as a topical antifungal agent.
4.6 g sodium were dissolved in 150 ml ethanol and 27.4 g (0.2 mol)
salicylamide added. The solution was refluxed gently and 24.6 g (0.2mol) nhexyl-
bromide added gradually. The mixture was refluxed for six hours, the
precipitated sodium bromide filtered off, and most of the alcohol removed by
distillation. Water was then added to the residue, and the 2-nhexyloxybenzamide
filtered off. It crystallized from 50% aqueous ethanol in
colorless crystals, MP 71°C.
