ChemicalBook > Product Catalog > API > Nervous system drugs > Sedative and hypnotic > Sodium bromide
Basic information Physical and chemical properties Chemical Properties Uses Production method Toxicity Safety Related Supplier
Sodium bromide Chemical Properties
- Melting point:755 °C (lit.)
- Boiling point:1390 °C
- Density 3,203 g/cm3
- vapor pressure 1 mm Hg ( 806 °C)
- refractive index 1.6412
- Flash point:1390°C
- storage temp. Store at room temperature.
- solubility H2O: 1 M at 20 °C, clear, colorless
- form Powder
- color White
- Specific Gravity3.21
- PH5.74 (430g/l, H2O, 22.5℃)
- Water Solubility 905 g/L (20 ºC)
- Sensitive Hygroscopic
- λmaxλ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
- Merck 14,8594
- BRN 3587179
- Stability:Stable. Incompatible with strong acids. Hygroscopic.
- CAS DataBase Reference7647-15-6(CAS DataBase Reference)
- NIST Chemistry ReferenceSodium bromide(7647-15-6)
- EPA Substance Registry SystemSodium bromide (7647-15-6)
Sodium bromide Usage And Synthesis
- Physical and chemical propertiessodium bromide is a colorless cubic crystal or white granular powder, and belongs to isometric system. It is odorless, and has slightly bitter and briny taste but high toxicity. It is easily to absorb moisture and caking but without deliquescence. It is slightly soluble in alcohol and easily soluble in water (at 100 °C, the solubility in 100ml water solubility is 121g), its aqueous solution is neutral with electronic conductivity. The anhydrous sodium bromide crystal will be precipitated out at 51°C with dihydrate compound forming at temperature lower than 51 °C. Its bromide ion can be substituted by fluorine, and chlorine. Under acidic conditions, it can be oxidized by oxygen and release free bromine; this process is taken advantage of by industry for producing bromine. It can have reaction with dilute sulfuric acid to produce hydrogen bromide. However, hydrobromic acid is a strong acid which can’t be produced through the reaction with dilute sulfuric acid and can only made through high-boiling point acid to make low-boiling point acid. However, we should avoid to use concentrated sulfuric acid which has strong oxidation effect and thus converting bromine (-1) into bromine element and release reddish-brown gas. This method can be used to identify sodium iodide (Heating sodium iodide and concentrated sulfuric acid together will release red-purple gases), Thereby, we can only take the concentrated phosphoric acid together with sodium bromine for heating to produce hydrogen bromine.
Bromide ions can enhance the inhibitor process of brain cortex, and promote their concentration. Therefore, medically it can be used as tranquilizers, and hypnotic or anticonvulsant drugs. When human swallow or inhale the compounds, it will cause harm to central nervous system, brain, and eye while causing irritation response of skin, eyes and also the respiratory tract.
- Chemical PropertiesSodium bromide is a colorless cubic crystal or white granular powder. It is odorless, and has slightly bitter and briny taste but high toxicity. It is easily soluble in water (at 100 °C, the solubility in 100ml water solubility is 121g), but slightly soluble in alcohol.
- Sodium bromide can be used as raw material in the preparation of liquid photographic film; medically as sedative, the brominating agent in printing and dyeing; it can also be used in synthetic fragrances and other chemicals.
- Photographic industry applies it for the preparation of liquid photosensitive film. It is medically used for the production of diuretics and sedatives. Perfume industry uses it for the production of synthetic fragrances. Printing and dyeing industry use it as a brominating agent. In addition, it can be also be used for organic synthesis and so on.
- Sodium bromide is used for the photographic industry, spices, pharmaceutical and printing industries.
- It is used for the reagents for analysis, and can also be used for the synthesis of inorganic and organic compounds and pharmaceutical industry.
- It is sued for photographic film, medicines, perfumes, dyes and other industries.
- It can be applied to determination of trace cadmium and Manufacturing of bromide. It can also be applied to inorganic and organic synthesis, photogravure and pharmaceuticals.
- Production methodUrea reduction: dissolve soda ash (sodium carbonate), urea in hot water, and fed into the reactor; gradually add bromine for reaction and generate sodium bromide. Then further add active carbon for decolorization; further undergo filtration, evaporation, crystallization, centrifugal separation, and drying to obtain sodium bromide products. The reaction is as following：
3Br2 + 3Na2CO3 + NH2CONH2 → 6NaBr + 4CO2 ↑ + N2 ↑ + 2H2O
Neutralization method: add about 40% hydrobromic acid into the reactor, stir and slowly add 40% caustic solution for neutralization to Ph 7.5~8 for generating sodium bromide; after isolated by centrifugation, evaporation, crystallization and centrifuged again separation, then we can obtain the final product of sodium bromide. the reaction is:
HBr + NaOH → NaBr + H2O
- ToxicityWe should prevent its ingestion and inhalation; avoid the contact of eye and skin with it. If intake or inhalation happens, adverse reactions include dizziness, nausea, and vomiting can occur. In these cases, we should immediately consult a doctor for treatment. Upon being splashed in the eyes, we should immediately rinse with fresh water for 20 min; upon skin contact with sodium bromide, we should also rinse with plenty of water.
- Chemical PropertiesSodiumbromide, NaBr,is a white, hygroscopic, crystalline solid with a bitter, saline taste.It is water soluble,with a melting point of 758°C (1400 OF). Sodium bromide is used in medicine as a sedative and in photography in the preparation of silver bromide emulsion on photographic plates or films.
- Physical propertiesWhite crystalline powder or granules; saline and slight bitter taste; cubic structure; density 3.20 g/cm3; melts at 747° C; vaporizes at 1,390°C; vapor pressure 1 torr at 806°C and 5 torr at 903°; highly soluble in methanol, 16.7 g/100mL.
The dihydrate is a white crystalline solid; density 2.18 g/cm3; decomposes at 36°C; soluble in water; sparingly soluble in methanol.
- OccurrenceSodium bromide occurs in seawater at an average concentration of 0.008%. It also is found naturally in some salt deposits. It is used in photography for preparing light-sensitive silver bromide emulsions. The salt also is used as a bleaching and disinfecting agent for water treatement in swimming pools, health spas, and hot tubs. Other uses are as a catalyst for partial oxidation of hydrocarbons, for increasing density of aqueous drillng fluids for oil wells, as an electrolyte component in sodium-halogen batteries, as a brominating agent in organic synthesis, in preparing bromide salts, and as a laboratory reagent. Sodium bromide is used in medicine as a sedative and hypnotic.
- UsesIn photography.
- UsesSodium Bromide is a high-tonnage chemical and one of the most important of the bromide salts (NaBr2). High-purity grades are required in the formulation of silver bromide emulsions for photography. The compound, usually in combination with hypochlorites, is used as a bleach, notably for cellulosics. The production of sodium bromide simply involves the neutralization of HBr with NaOH or with sodium carbonate or bicarbonate.
- PreparationSodium bromide can be prepared by several methods. Pure salt can be made by neutralizing sodium hydroxide or sodium carbonate with hydrobromic acid. The solution is evaporated for crystallization:NaOH + HBr → NaBr + H2O NaCO3 + HBr → NaBr + CO2 + H2O
Sodium bromide can be made by passing bromine through an aqueous solution of sodium hydroxide or carbonate in the presence of a reducing agent, such as ammonia, hydrazine, activated charcoal, or Fe2+ ion. A typical method involves adding iron to bromine water to form ferrosoferric bromide, Fe[FeBr5]. This double salt is dissolved in excess water followed by addition of sodium carbonate. The product mixture is filtered and the filtrate is evaporated to crystallize sodium bromide. The overall reaction may be written as follows: 3Fe + 4Br2 + 4Na2CO3 → 8NaBr + FeCO3 + Fe2(CO3)3
Another method involves adding excess bromine to a solution of sodium hydroxide. This forms sodium bromide and bromate. The product solution is evapoated to dryness. The bromate is reduced to bromide by heating with carbon: 3Br2 + 2NaOH + H2O → NaBr + NaBrO3 + 4HBr.
- DefinitionChEBI: An inorganic sodium salt having bromide as the counterion.
- Definitionsodium bromide: A white crystallinesolid, NaBr, known chiefly asthe dihydrate (monoclinic; r.d. 2.17),and as the anhydrous salt (cubic; r.d.3.20; m.p. 747°C; b.p. 1390°C). The dihydrateloses water at about 52°Cand is very slightly soluble in alcohol.Sodium bromide is prepared by thereaction of bromine on hot sodiumhydroxide solution or of hydrogenbromide on sodium carbonate solution.It is used in photographic processingand in analytical chemistry.
- HazardToxic by inhalation and ingestion.
- Safety ProfileModerately toxic by ingestion. Experimental reproductive effects. Incompatible with acids, alkaloidal and heavy-metal salts. When heated to decomposition it emits toxic fumes of Brand NazO. See also BROMIDES.
- Purification MethodsCrystallise the bromide from water (0.86mL/g) between 50o and 0o, and dry it at 140o under vacuum (this purification may not eliminate chloride ion).
Sodium bromide Preparation Products And Raw materials
- Raw materialsSodium hydroxideSodium carbonateBromineUreaHydrogen bromideLithium bromide
- Preparation ProductsPhenethyl alcohol(S)-(-)-7,7'-BIS[DI(3,5-DIMETHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE(R)-7,7'-BIS(DIPHENYLPHOSPHINO)-1,1'-SPIROBIINDANE(S)-1,1'-SPIROBIINDANE-7,7'-DIOL(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1PHENYLETHYL]AMINE(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-PHENOXY2-Amino-4-chloropyridine2-[3-(2H-Benzotriazol-2-yl)-4-hydroxyphenyl]ethyl methacrylate4-Bromotoluene(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-DIMETHYLAMINE3-CARBOXY-4-CHLOROBENZENEBORONIC ACID1,1'-SPIROBIINDANE-7,7'-DIOL4-Aminobenzotrifluoride3-Azetidinecarboxylic acid4-Chloro-2-fluorophenylboronic acid2-Aminopyridin-4-ol3-METHYLGLUTARIC ACID5-BROMO-8-METHOXY-2-METHYL-QUINOLINEStyrene oxideTRICOSANOIC ACID4-Chloropyridine-2-carboxamideN-(Tetrahydro-2-furoylcarbonyl)piperazine hydrobromide2-BROMO-5-METHYLBENZOIC ACID14-METHYLPENTADECANOIC ACIDOCTACOSANOIC ACID2-Bromo-6-methylbenzoic acid6-ACETHYOXY-8-METHYL-8-AZABICYCLO(3.2.1)OCTAN-3-ONELIGNOCERIC ACID1,3-CYCLOHEXADIENEN,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride1-N-PROPYLPIPERAZINE DIHYDROBROMIDE4-(BROMOMETHYL)-3-NITROBENZOIC ACID4-BUTOXYANILINE2-Bromo-5-nitrothiazole2-(2-Bromoethyl)-1,3-dioxolaneProbenecidDyclonine hydrochloride
- IRON (III) BROMIDE Magnesium bromide Cupric bromide Magnesium bromide GERANYL BROMIDE Copper(I) bromide-dimethyl sulfide Cuprous bromide NICKEL(II) BROMIDE TRIHYDRATE Bromoacetyl bromide Cesium bromide Ammonium bromide Potassium bromide Calcium bromide NICKEL BROMATE Zinc bromide Ethidium bromide Lithium bromide INDIUM(III) BROMIDE
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