Isobutyl acetoacetate has a sweet, winey, brandy-like odor and a
sweet and slightly fruity flavor. May be prepared from isobutyl
acetate by heating in the presence of sodium isobutylate.
Isobutyl acetoacetate has a sweet, winy, brandy-like odor and a sweet and slightly fruity flavor.
Isobutyl acetoacetate is a clear colorless liquid. Insoluble in water, soluble in
alcohol and oils. B.P. approximately 196℃. The odor is somewhat fresher, not as "fermented" as that of the n-But yiester, while the
taste of the iso-Butylester is somewhat less sweet. In general, the former is preferred for
“winey” effects, while this (latter) is preferred
for fruity effects, and partly as a fixative for
the more volatile esters used in hard candy
flavoring etc. Concentrations are usually around 25 ppm.
Isobutyl Acetoacetate is a building block that has been used as a reactant in the preparation of b-annulated 1,4-dihydropyridine derivatives as TGFβ signaling inhibitors.
Isobutyl acetoacetate is used as intermediate for the production of pharmaceuticals (e.g. Nisoldipine). Product Data Sheet
ChEBI: 2-Methylpropyl 3-oxobutanoate is an oxo carboxylic acid.
From isobutyl acetate by heating in the presence of sodium isobutylate. Or by Claisen condensation of iso-ButyI
acetate with Ethylacetate, using Sodium
ethoxide catalyst.
