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Acetyl tributyl citrate

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Acetyl tributyl citrate Basic information
Acetyl tributyl citrate Chemical Properties
Safety Information
MSDS
Acetyl tributyl citrate Usage And Synthesis
  • Chemical Propertiesclear colorless liquid
  • Chemical PropertiesAcetyltributyl citrate is a clear, odorless, practically colorless, oily liquid.
  • Chemical PropertiesTributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has a mild, fruity, nondescript flavor.
  • Chemical PropertiesAcetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents.
  • UsesLabelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.
  • Usesplasticizer flavoring agent
  • DefinitionAqueous-based pharmaceutical coat- ings.
  • PreparationFrom citric acid via the tributyl ester followed by acetylation.
  • Production MethodsAcetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.
  • Pharmaceutical ApplicationsAcetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.
  • Safety ProfileWhen heated to decomposition it emits acrid smoke and irritating fumes. ADD750
  • Safetyand films intended for direct food contact. It is also used in selfadhesive thin films used for topical delivery systems. It is generally regarded as a relatively nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
    LD50 (cat, oral): >50 mL/kg
    LD50 (mouse, IP): >4 g/kg
    LD50 (rat, oral): >31.5 g/kg
  • CarcinogenicityThe chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.
  • storageAcetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.
  • IncompatibilitiesAcetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.
  • Regulatory StatusIncluded in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.
Acetyl tributyl citrate Preparation Products And Raw materials
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