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Triethyl acetyl citrate

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Triethyl acetyl citrate Basic information
Triethyl acetyl citrate Chemical Properties
Safety Information
  • Safety Statements 23-24/25
  • WGK Germany 1
  • RTECS GE8225000
  • HS Code 2918150000
MSDS
Triethyl acetyl citrate Usage And Synthesis
  • Chemical PropertiesAcetyltriethyl citrate occurs as a clear, odorless, practically colorless oily liquid.
  • UsesATEC is produced by the reaction of citric acid triethyl ester with acetic acid anhydride. It is used as a solvent plasticizer for cellulose nitrate and cellulose acetate.
  • Production MethodsAcetyltriethyl citrate is prepared by the esterification of citric acid with ethanol followed by acylation with acetic anhydride.
  • DefinitionAqueous-based pharmaceutical coat- ings.
  • Pharmaceutical ApplicationsAcetyltriethyl citrate is used to plasticize polymers in formulated pharmaceutical coatings. The coating applications include capsules, tablets, beads and granules for taste masking, immediate release, sustained-release and enteric formulations. It is also used in diffusion-controlled release drug delivery systems.
  • SafetyAcetyltriethyl citrate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
    LD50 (cat, oral): 8.5 g/kg
    LD50 (mouse, IP): 1.15 g/kg
    LD50 (rat, oral): 7 g/kg
  • storageAcetyltriethyl citrate should be stored in dry, closed containers at temperatures not exceeding 388℃. When stored in accordance with these conditions, acetyltriethyl citrate is a stable product.
  • IncompatibilitiesAcetyltriethyl citrate is incompatible with strong alkalis and oxidizing materials.
  • Regulatory StatusApproved in the USA for direct food contact in food films.
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