ω-Pentadecalactone has an extraordinarily persistent, musk-like odor.
Cyclopentadecanolide occurs in small quantities in,
for example, angelica root oil. It forms colorless crystals (mp 37–38°C) with a
delicate, musk-like odor.
Cyclopentadecanolide is a white crystalline low melting solid. melting at
36-37℃. to a colorless, viscous oil. B.P. 280℃. Delicately animal, musky and sweet, extremely tenacious odor of outstanding uniformity. Common use level in the perfume oil is
about 0.1 to 0.4%.
Originally reported found in the essential oil from angelica roots.
Pentadecanolide is a monomer used to make PGA-co-pentadecalactone polymers to be used in the development of directly compressed prolonged release tablets of slightly soluble drugs such as ketoprofen.
As a fixative in perfumery.
Pentadecanolide may be used for the synthesis of poly(pentadecanolide) (PPDL) by Novozyme 435 catalyzed ring-opening polymerization. It may be employed as starting reagent for the synthesis of terminally-branched iso-fatty acids (iso-C15-C17).
ChEBI: Cyclopentadecanolide is a macrolide.
Cyclopentadecanolide gives highly interesting effects when applied to certain flavors,
e. g. alcoholic beverages, dentifrice flavors etc.
There is very often a unanimous preference
for the flavor that is properly treated with the
hctone. Concentration in such flavors may be about
0.02 to 1.50 ppm calculated upon the finished
consumer product. However, it should be
kept in mind, that dentifrices are flavored at
extremely high concentration (about 100) and
it may therefore ghe an underestimated evaluation of the power of this Lactone, The most
frequent abuse of Cyclopentadecanolide is
that of over-dosage. It is also used extensively in Berry flavors, Liquor, Wine, Brandy, Fruit, Nut, Vanilla copositions, etc.
The main industrial syntheses start from compounds produced
from cyclododecatriene: either by ring expansion of cyclododecanone or
by depolymerization of polyesters of 15-hydroxypentadecanoic acid (from
1,12-dodecanediol).
Taste characteristics at 75 ppm: vanilla bean, powdery helioropine, creamy and licorice.
Pentadecanolide is one of the major components, isolated from the root of Angelica archangelica L., species. It is a synthetic musk, which exists as a widespread contaminant in the environment.
Flammability and Explosibility
Non flammable
Macrolide® (Symrise), Exaltolide®, Exaltolide®Total (Firmenich),
Pentalide (Soda Aromatic).
It has been recrystallised from MeOH (4 parts) at -15o. [Hundieck
