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TRIOXSALEN

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TRIOXSALEN Basic information
TRIOXSALEN Chemical Properties
  • Melting point:229-231 °C(lit.)
  • Boiling point:310.05°C (rough estimate)
  • Density 1.2196 (rough estimate)
  • refractive index 1.5557 (estimate)
  • storage temp. 2-8°C
  • solubility DMSO: soluble
  • form powder
  • color white
  • Merck 14,9735
  • BRN 221723
  • CAS DataBase Reference3902-71-4
  • EPA Substance Registry System7H-Furo[3,2-g][1]benzopyran-7-one, 2,5,9-trimethyl- (3902-71-4)
Safety Information
  • Hazard Codes C
  • Risk Statements 34-40
  • Safety Statements 26-36/37/39-45
  • RIDADR UN 1759 8/PG 1
  • WGK Germany 2
  • RTECS LV1576000
  • 8-10
  • TSCA Yes
  • HazardClass 8
  • PackingGroup III
  • HS Code 29322985
MSDS
TRIOXSALEN Usage And Synthesis
  • Chemical PropertiesWhite to slightly beige crystalline powder
  • Usesmelanizing agent, antipsoriatic
  • DefinitionChEBI: 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phot therapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermi .
  • brand nameTrisoralen (Valeant).
  • Purification MethodsPurify trioxsalen by recrystallisation from CHCl3. If too impure, it is fractionally crystallised from CHCl3/pet ether (b 30-60o) using Norit and finally crystallised from CHCl3 alone to give colourless prisms, m 234.5-235o. It is a photosensitiser so it should be stored in the dark. [UV: Kaufmann J Org Chem 26 117 1961, Baeme et al. J Chem Soc 2976 1949, Beilstein 19/4 V 472.]
TRIOXSALEN Preparation Products And Raw materials
TRIOXSALEN(3902-71-4)Related Product Information
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