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Estradiol benzoate

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Estradiol benzoate Basic information
Estradiol benzoate Chemical Properties
  • Melting point:191-198 °C(lit.)
  • alpha D25 +58 to +63° (c = 2 in dioxane)
  • Boiling point:465.03°C (rough estimate)
  • Density 1.0493 (rough estimate)
  • refractive index 1.5460 (estimate)
  • storage temp. 2-8°C
  • solubility Practically insoluble in water, freely soluble in methylene chloride, sparingly soluble in acetone, slightly soluble in methanol.
  • form neat
  • Water Solubility 0.4mg/L(25 ºC)
  • Merck 3703
  • BRN 3107526
  • CAS DataBase Reference50-50-0(CAS DataBase Reference)
  • NIST Chemistry ReferenceEstradiol benzoate(50-50-0)
Safety Information
MSDS
Estradiol benzoate Usage And Synthesis
  • Chemical PropertiesWhite solid
  • Usesantiacne, antineoplastic
  • UsesEstradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position. Estradiol benzoate is useful in the tr eatment of lesions produced by diminution of bodily production of estrogens.
  • DefinitionChEBI: A benzoate ester resulting from the formal condensation of benzoic acid with the phenolic hydroxy group of 17beta-estradiol.
  • Clinical UseEstradiol is a semisynthetic estrogen compound. Its effects will mimic that of estrogen in animals. The most common use in small animals has been to terminate pregnancy.
    Estradiol benzoate also has been used to terminate pregnancy (5-10 mg/kg divided into two or three SQ injections). Estradiol cypionate formulation had high efficacy (95%), but it had serious adverse effects and is not recommended. Estradiol cypionate is longer acting and more potent than other estrogen formulations. Estradiol valerate injection (20 mg/mL) is also available for human medicine to treat hypoestrogenism.
  • Safety ProfileConfirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human reproductive effects by intramuscular route: menstrual cycle changes and disorders. Experimental reproductive effects. Mutation data reported. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTRADIOL.
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