Chemical Properties
White solid
Uses
antiacne, antineoplastic
Uses
Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position. Estradiol benzoate is useful in the treatment of lesions produced by diminution of bodily production of estrogens.
Definition
ChEBI: A benzoate ester resulting from the formal condensation of benzoic acid with the phenolic hydroxy group of 17beta-estradiol.
Clinical Use
Estradiol is a semisynthetic estrogen compound. Its effects will mimic that of estrogen in animals. The most common use in small animals has been to terminate pregnancy.
Estradiol benzoate also has been used to terminate pregnancy (5-10 mg/kg divided into two or three SQ injections). Estradiol cypionate formulation had high efficacy (95%), but it had serious adverse effects and is not recommended. Estradiol cypionate is longer acting and more potent than other estrogen formulations. Estradiol valerate injection (20 mg/mL) is also available for human medicine to treat hypoestrogenism.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic,
tumorigenic, and teratogenic data. Human
reproductive effects by intramuscular route:
menstrual cycle changes and disorders.
Experimental reproductive effects. Mutation
data reported. A steroid. When heated to
decomposition it emits acrid smoke and
irritating fumes. See also ESTRADIOL.
