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Estradiol

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Estradiol Basic information
Estradiol Chemical Properties
Safety Information
  • Hazard Codes T,Xn
  • Risk Statements 45-48-40
  • Safety Statements 53-45-24/25-22
  • RIDADR UN 2811 6.1/PG 2
  • WGK Germany 3
  • RTECS KG3750000
  • 8-10
  • HS Code 29372390
MSDS
Estradiol Usage And Synthesis
  • Chemical PropertiesWhite Solid
  • UsesEstradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.
  • DefinitionChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).
  • Biological ActivityEndogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).
  • Purification Methods17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o.
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