57-91-0
基本信息
17-ALPHA-雌二醇
alpha-雌二醇
α-雌二醇
1,3,5(10)雌甾三烯-3,17Α-二醇
17Α-雌二醇
3,17Α-二羟基-1,3,5(10)雌甾三烯
表雌二醇
雌甾-1,3,5(10)三烯-3,17Α-二醇
雌二醇(炔雌醇)
雌二醇
1,3,5(10)-ESTRATRIEN-2,17BETA-DIOL
1,3,5(10)-ESTRATRIEN-3,17-ALPHA-DIOL
1,3,5(10)-ESTRATRIEN-3,17-BETA-DIOL
1,3,5(10)-ESTRATRIEN-3,17-DIOL
1,3,5[10]-ESTRATRIENE-3,17ALPHA-DIOL
1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL
1,3,5-ESTRATRIENE-3,17-BETA-DIOL
17A-ESTRADIOL
17ALPHA-ESTRADIOL
17B-ESTRADIOL
17BETA-ESTRADIOL
17BETA-OESTRADIOL
3,17ALPHA-DIHYDROXY-1,3,5[10]-ESTRATRIENE
3,17BETA-DIHYDROXY-1,3,5[10]-ESTRATRIENE
3,17-DIHYDROXYESTRATRIENE
(8R,9S,13S,14S,17S)-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL
ALPHA-ESTRADIOL
B-ESTRADIOL
BETA-ESTRADIOL
物理化学性质
| 熔点 | 176-180 °C(lit.) |
| 熔点 | 176-180 °C(lit.) |
| 比旋光度 | D20 +53 to +56° (c = 0.9 in dioxane) |
| 沸点 | 355.44°C (rough estimate) |
| 密度 | 1.0708 (rough estimate) |
| 折射率 | 1.4800 (estimate) |
| 储存条件 | 0-6°C |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | ethanol: 50 mg/mL, clear, colorless |
| 溶解度 | 乙醇：50 mg/mL，澄清，无色 |
| 酸度系数(pKa) | 10.27±0.60(Predicted) |
| 形态 | powder |
| 颜色 | white with slight yellow cast |
| 水溶解性 | 3.9mg/L(25 ºC) |
| Merck | 13,3738 |
| Merck | 14,3704 |
| CAS 数据库 | 57-91-0(CAS DataBase Reference) |
| NIST化学物质信息 | Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0) |
| EPA化学物质信息 | Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0) |
安全数据
| 危险性符号(GHS) |   GHS08,GHS09 |
| 警示词 | 危险 |
| 危险性描述 | H341-H351-H360F-H362-H410 |
| 防范说明 | P201-P202-P260-P263-P273-P308+P313 |
| 危险品标志 | T,Xn |
| 危险类别码 | 45-48-40 |
| 危险类别码 | R45-R48-R40 |
| 安全说明 | 53-45-24/25-22 |
| 安全说明 | S53-S45-S24/25-S22 |
| 危险品运输编号 | UN 2811 6.1/PG 2 |
| 危险品运输编号 | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| WGK Germany | 3 |
| RTECS号 | KG3750000 |
| F | 8-10 |
| 海关编码 | 29372390 |
应用领域
知名试剂公司产品信息
α-雌二醇价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/11 | XW00579101 | Α-雌二醇 | 57-91-0 | 200MG | 229元 |
| 2024/11/08 | HY-B0141A | α-雌二醇 Alpha-Estradiol | 57-91-0 | 100mg | 750元 |
| 2024/11/08 | HY-B0141A | α-雌二醇 Alpha-Estradiol | 57-91-0 | 10mM * 1mLin DMSO | 825元 |
常见问题列表
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Human Endogenous Metabolite
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Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression.
Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17.