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Estradiol valerate

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Estradiol valerate Basic information
Estradiol valerate Chemical Properties
  • Melting point:144°C
  • Boiling point:438.83°C (rough estimate)
  • Density 1.1024 (rough estimate)
  • refractive index 1.4700 (estimate)
  • storage temp. Sealed in dry,Room Temperature
  • solubility Practically insoluble in water, soluble in alcohol.
  • form neat
  • pka10.25±0.60(Predicted)
  • Merck 13,3738
  • BRN 2480357
  • CAS DataBase Reference979-32-8(CAS DataBase Reference)
Safety Information
  • Hazard Codes T
  • Risk Statements 60-61
  • Safety Statements 53-45
  • WGK Germany 3
  • RTECS KG5793000
  • HS Code 29372390
Estradiol valerate Usage And Synthesis
  • Chemical PropertiesOff-White Solid
  • OriginatorDelestrogen,Squibb,US,1954
  • UsesEstradiol (E888000) derivative. An estrogen.
  • Manufacturing Process2.3 parts of estradiol are mixed with 12 parts of pyridine and 10 parts of nvaleric anhydride and the mixture is heated for some time at 115°C in the oil bath. The cooled solution is mixed with 250 parts of water, whereupon an oil separates; this is extracted with ether. The separated ethereal solution is washed successively with N sulfuric acid, water, N sodium carbonate solution and water and then dried. The ether is then removed and the residue purified by distillation in a high vacuum. The estradiol di-n-valerate forms a yellowish oil according to US Patent 2,205,627.
    1 part of estradiol-3,17-n-divalerianate (boiling point at 0.01 mm = 220° to 230°C bath temperature; made, e.g., by the action of n-valeric anhydride on a solution of estradiol in pyridine) is mixed with 50 parts of a solution of 0.5% strength of potassium carbonate in methyl alcohol of 95% strength, and the whole is stirred for some time at 20°C. The oily n-di-valerianate passes gradually into solution. The solution is neutralized and the precipitate is produced by the addition of about 200 parts of water. This finely crystalline product is filtered and washed successively with water, dilute sodium carbonate solution and again with water. It may be further purified by crystallization from a mixture of methyl alcohol and water. The estradiol-17- mono-n-valerianate melts at 144° to 145°C according to US Patent 2,233,025.
  • brand nameDelestrogen (King).
  • Therapeutic FunctionEstrogen
  • Safety ProfileSuspected carcinogen with carcinogenic and teratogenic data. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTRADIOL.
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