Magnesium Valproate is an anticonvulsant agent and the effects it exerts are the result of valproic acid and magnesium acting in a complementary way. Magnesium valproate is effective as monotherapy in patients with newly diagnosed or previously treated partial or generalised epilepsy.
Moderately toxic by
ingestion. Danger: A spontaneously
combustible solid. When heated to
decomposition it emits toxic vapors of
magnesium.
Diethyl malonate is alkylated with 1-bromopropane and then hydrolyzed and decarboxylated to afford Magnesium valproate.
Valproic acid and its salt Magnesium Valproate is major antiepileptic drugs for the treatment of absence, myoclonic, and generalized tonic – clonic seizures and also may be effective against complex partial seizures. The most cited mechanisms are the increase in GABA function and the blockade of voltage-dependent Na+-channels. The most common side effects are gastrointestinal disturbances and sedation. The most serious adverse effect is liver damage, although this is rare. Teratogenic effects, predominantly spina bifida, are reported frequently.
