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Antipyrine Basic information
Antipyrine Chemical Properties
  • Melting point:109-111 °C(lit.)
  • Boiling point:319 °C
  • Density 1,19 g/cm3
  • refractive index 1.5850 (estimate)
  • storage temp. 2-8°C
  • solubility H2O: soluble1 gm in less than 1ml
  • pkapKa 1.4 (Uncertain)
  • form Crystalline Powder
  • color White
  • Water Solubility 1000 g/L (20 ºC)
  • Merck 14,716
  • BRN 157775
  • Stability:Stable. Incompatible with ammonia, strong acids, alkalies, strong oxidizing agents, metallic salts, phenol.
  • CAS DataBase Reference60-80-0(CAS DataBase Reference)
  • NIST Chemistry ReferenceAntipyrine(60-80-0)
  • EPA Substance Registry SystemAntipyrine (60-80-0)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22-36/37/38
  • Safety Statements 26-36-37/39
  • RIDADR 3249
  • WGK Germany 1
  • RTECS CD2450000
  • 10
  • TSCA Yes
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29331190
  • ToxicityLD50 orally in rats: 1.8 g/kg (Hart)
Antipyrine Usage And Synthesis
  • Chemical PropertiesWhite Powder
  • UsesAnalgesic; used to test hepatic drug-metabolizing activity.
  • Uses
    Antipyrine has been used for immunoblotting. It has also been used as an internal reference marker for studying the transport characteristics of platinum-containing drug, cisplatin in the human placenta in vitro.
  • DefinitionChEBI: A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at C-1 and C-5 and with a phenyl group at N-2.
  • brand nameAerol;Antigestin;Asthma dellipsoids;Aurafair;Auralgicin;Auraltone;Bajumol;Breezeazy;Calmasmin;Cetussan;Codalgin;Crema antisolar evanescente;Doleron novum;Dolo-med-much;Dol-stop;Kalopsis;Lanceotic;Lavylgan;Mig-antos;Migranin;Natt-lunedon;Neo-felsol;Orecil;Otipyrin;Otosan-sulfan;Otothricinol;Palacaine;Pasta antisola;Pomada heridas;Prednefrin;Prefrin liquifilm;Prefrin z;Priatan;Prophyllen;Remolmed;Salicopil;Sedaural;Sedonan;Shhe 21;Spalt n;Tympagesic;Visublefarite.
  • World Health Organization (WHO)Phenazone is a pyrazolone derivative chemically related to aminophenazone. Some regulatory authorities have imposed restrictions on its use on these grounds. However, a recent international study showed no statisticallybased evidence of an association with agranulocytosis or aplastic anaemia. Nor does it share with aminophenazone the propensity to produce potentially carcinogenic nitrosamines.
  • Biochem/physiol ActionsAntipyrine also referred to as phenazone or phenazonum is an anti-inflammatory agent that possesses analgesic, antipyretic and platelet-inhibitory actions.
  • Safety ProfileA human Doison bv 1 i an unspecified route. Moderately toxic via ingestion, subcutaneous, and intravenous routes. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Purification MethodsAntipyrine crystallises from EtOH/water mixture, *benzene, *benzene/pet ether or hot water (charcoal), and the crystals are dried under a vacuum. [Beilstein 24 H 27, 24 III/IV 75.]
Antipyrine Preparation Products And Raw materials
Antipyrine(60-80-0)Related Product Information
  • Company Name:Jiangxi ravel Biotechnology Co.,Ltd Gold
  • Tel:400-880-2824
  • Company Name:Shanghai Longsheng chemical Co.,Ltd. Gold
  • Tel:13585536065 021-58099652-8005
  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
  • Tel:+86-18621169078 +86-021-61259100
  • Company Name:Alfa Aesar
  • Tel:400-610-6006