2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺
2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺
![2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 结构式](https://img.chemicalbook.com/CAS/GIF/410536-97-9.gif)
2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 性质
| 熔点 | 119-120℃ |
|---|---|
| 沸点 | 659.2±50.0 °C(Predicted) |
| 密度 | 1.16 |
| 储存条件 | -20°C |
| 溶解度 | 溶于 DMSO（高达 30 mg/ml）。 |
| 形态 | 黄色固体 |
| 酸度系数(pKa) | 7.85±0.50(Predicted) |
| 颜色 | 淡黄色低 |
| 水溶解性 | Soluble in water, DMSO and methanol |
| 稳定性 | 可在-20°下的DMSO中的溶液储存长达1个月。 |
| InChI | InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30) |
| InChIKey | UXJFDYIHRJGPFS-UHFFFAOYSA-N |
| SMILES | C(NC(C1=CC=CC=C1)C)(=O)C1=CC=CC=C1N=CC1=C2C(C=CC=C2)=CC=C1O |
2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 用途与合成方法
|
ySir2 48 μM (IC 50 ) |
hSIRT2 57.7 μM (IC 50 ) |
hSIRT1 131 μM (IC 50 ) |
Sirtinol reduces the growth of MCF-7 cells in a concentration- and time-dependent manner. The IC 50 values of sirtinol are 48.6 μM and 43.5 μM after 24 and 48 h of treatment, respectively. Sirtinol significantly decreases SIRT1 expression and increases the acetylated p53 level. Sirtinol attenuates the proliferation and induces apoptosis of nonsmall cell lung cancer (NSCLC) H1299 cells and causes the significantly increased level of FoxO3a, a proapoptotic transcription factor targeted by Sirt1.
Sirtinol has anti-inflammatory effects through direct inhibition of HNE activity and attenuates HNE-induced and LPS-mediated tissue or organ injury.
2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-13515R | 2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 | 410536-97-9 | 5 mg | 1375 |
| 2026-09-15 | HY-13515 | 2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 | 410536-97-9 | 1 mg | 250 |
