2,4,5-Trifluorobenzyl alcohol is an aryl fluorinated building block. It is also referred to as (2,4,5-trifluorophenyl)methanol [IUPAC name].
2,4,5-Trifluorobenzyl alcohol is an aryl fluorinated building block. It is also referred to as (2,4,5-trifluorophenyl)methanol [IUPAC name].
GENERAL METHOD: Sodium borohydride (0.28 g, 7.5 mmol) was added to a methanol (10 mL) solution of 2,4,5-trifluorobenzaldehyde (5 mmol) cooled in an ice bath in batches over a period of 20 minutes. The reaction mixture was stirred at room temperature for 30 min. The excess sodium borohydride was quenched by adding ice water. Subsequently, the reaction mixture was concentrated and the residue was dissolved in ethyl acetate and washed twice with deionized water. The organic phase was dried with anhydrous sodium sulfate and concentrated to give 2,4,5-trifluorobenzyl alcohol in 96% yield as a colorless oil. The spectral data of the resulting compound were in agreement with standard samples from commercial sources.
[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 2, p. 721 - 737
[2] Organic and Biomolecular Chemistry, 2014, vol. 12, # 30, p. 5781 - 5788
