Methyl 2-bromomethylbenzoate

89-71-4

2417-73-4

General procedure for the synthesis of methyl 2-bromomethylbenzoate from methyl o-toluate: (2) 1.50 g (10 mmol) of methyl o-toluate was added to a 250 mL round-bottom flask and dissolved in 80 mL of carbon tetrachloride. Subsequently 1.98 g (11 mmol) of N-bromosuccinimide (NBS) and 48 mg (0.2 mmol) of benzoyl peroxide (BPO) were added. The mixture was heated to reflux for 1.5 h to ensure complete reaction. Upon completion of the reaction, insoluble material was removed by filtration and the solvent was subsequently evaporated to give methyl 2-bromomethylbenzoate. The reaction was quantitative.