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Ziprasidone mesilate

Chemical Properties

Major Application	pharmaceutical (small molecule)
InChIKey	WLQZEFFFIUHSJB-UHFFFAOYSA-N
SMILES	C1(N2CCN(CC2)CCC2=CC3CC(=O)NC=3C=C2Cl)C2C=CC=CC=2SN=1.S(C)(O)(=O)=O.O.O.O

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Animal Model:	Eight-week-old female Sprague-Dawley rats weighing 200 to 250 g^[3]
Dosage:	20 mg/kg
Administration:	Oral gavage; 20 mg/kg; once daily; 7 weeks
Result:	Gained significantly less weight (P = 0.031), had a lower level of physical activity (P = 0.016), showed a higher resting energy expenditure (P < 0.001), and displayed a greater capacity for thermogenesis when subjected to cold (P < 0.001).